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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition

Figure 5

Transmembrane (tm)TNF reverse signaling induced apoptosis of monocytes correlates with change in disease activity after 12 weeks. (A, B) Box plots depict C-reactive protein (CRP) (A) and erythrocyte sedimentation rate (ESR) (B) at baseline (BL) (dark gray bars) and after 12 weeks of etanercept (light gray bars) in the groups with high tmTNF reverse signaling induced apoptosis (tmTNF RSA) and low tm tmTNF RSA separately (n = 20). Significant differences are as indicated. (C) Depicted are median and standard error of the mean of the numeric improvement (Δ) in disease activity score (DAS)28 in the patient group with high (solid squares, n = 11) and low (solid circles, n = 9) rates of tmTNF RSA at the indicated time points. For significant differences between ΔDAS28 in both groups at the different time points, the levels of significance are indicated: *P <0.05, **P <0.01). (D) Dot plot depicts the rate of tmTNF RSA in patients achieving a good therapeutic response after 12 weeks of etanercept (responder, Resp) and in patients with only a moderate or no response (nonresponders, Nonresp). Significant differences are as indicated.

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