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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition

Figure 6

Schematic representation of the magnitude of spontaneous in vitro apoptosis (SIA) and transmembrane TNF reverse signaling-induced apoptosis (tmTNF RSA) in healthy donors (HD) and patients with rheumatoid arthritis (RA). A shift from SIA towards tmTNF RSA is associated with both disease severity and the clinical response under anti-TNF treatment.

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Arthritis Research & Therapy

ISSN: 1478-6362

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