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Table 1 Allelic association analysis of the twelve chromosome 11 SNPs with gout

From: Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

  

East Polynesian (EP) (High)

East Polynesian (Low)

West Polynesian (WP)

East/West Polynesian

European Caucasian

SNPb

Chr:Posc

Effect/Otherd

Allele Freq.

ORe(95% CI)

P e

Allele Freq.

ORe(95% CI)

P e

Allele Freq.

ORe(95% CI)

P e

Allele Freq.

ORe(95% CI)

P e

Allele Freq.

ORe(95% CI)

P e

Case

Con

Case

Con

Case

Con

Case

Con

Case

Con

1a

  

T/C

0.571

0.531

1.19

0.257

0.566

0.601

1.01

0.957

0.403

0.409

1.06

0.758

0.500

0.400

1.65

0.412

0.566

0.564

1.02

0.868

(0.88,1.61)

(0.63,1.64)

(0.75,1.49)

(0.50,5.48)

(0.84,1.24)

1

rs17299124

11:64256859

C/A

0.976

0.950

2.77

0.019

0.821

0.801

1.20

0.577

0.994

0.957

5.65

0.011

0.974

0.947

3.00

0.461

0.733

0.752

0.91

0.401

(1.18,6.50)

(0.63,2.32)

(1.49,21.39)

(0.16,55.71)

(0.73,1.14)

2

rs693591

11:64325069

C/G

0.522

0.449

1.41

0.031

0.315

0.291

1.13

0.630

0.373

0.367

1.00

0.992

0.526

0.260

4.55

0.025

0.139

0.135

0.95

0.733

(1.03,1.92)

(0.68,1.89)

(0.72,1.40)

(1.21,17.06)

(0.72-1.26)

2

rs17300741

11:64331462

A/G

0.819

0.789

1.30

0.187

0.604

0.557

1.29

0.312

0.808

0.830

0.76

0.213

0.806

0.750

1.42

0.595

0.476

0.439

1.05

0.611

(0.88,1.91)

(0.78,2.14)

(0.49,1.17)

(0.39,5.24)

(0.87,1.27)

2

rs2078267

11:64334114

C/T

0.938

0.910

1.78

0.063

0.651

0.606

1.19

0.526

0.980

0.944

2.20

0.071

0.921

0.886

1.21

0.815

0.479

0.456

0.98

0.816

(0.97,3.26)

(0.70,2.00)

(0.94,5.17)

(0.24,6.11)

([0.81,1.18]

3

rs3825018

11:64358809

G/A

0.739

0.674

1.46

0.028

0.500

0.447

1.37

0.206

0.726

0.712

1.16

0.404

0.842

0.660

1.83

0.316

0.305

0.267

1.22

0.065

(1.04,2.06)]

(0.84,2.23)

(0.82,1.66)

(0.56,5.98)

(0.99,1.50)

3

rs475688

11:64364291

T/C

0.433

0.427

1.10

0.543

0.370

0.295

1.66

0.073

0.409

0.461

0.78

0.145

0.556

0.420

1.72

0.391

0.269

0.236

1.26

0.043

(0.80,1.52)

(0.95,2.89)

(0.56,1.09)

(0.50,5.97)

([1.01,1.57)

3

rs7932775

11:64367862

C/T

0.496

0.478

1.03

0.866

0.373

0.320

1.36

0.278

0.489

0.415

1.49

0.019

0.500

0.396

1.00

1.000

0.213

0.174

1.32

0.033

(0.76,1.40)

(0.78,2.35)

(1.07,2.09)

(0.35,2.90)

(1.02,1.69)

3

rs476037

11:64369540

A/G

0.254

0.206

1.56

0.022

0.149

0.136

1.10

0.787

0.250

0.303

0.78

0.165

0.368

0.250

2.58

0.161

0.088

0.089

1.03

0.846

(1.07,2.28)

(0.56,2.16)

(0.55,1.11)

(0.69,9.68)

(0.74,1.43)

3

rs478607

11:64478063

G/A

0.241

0.268

0.85

0.359

0.279

0.184

1.72

0.080

0.196

0.166

1.48

0.085

0.211

0.225

0.82

0.766

0.167

0.144

1.27

0.077

(0.60,1.20)

(0.94,3.15)

(0.95,2.31)

(0.23,2.98)

(0.98,1.66)

4

rs12289836

11:65436888

A/G

0.621

0.622

0.94

0.711

0.660

0.631

1.07

0.810

0.693

0.746

0.80

0.237

0.790

0.725

1.22

0.766

0.645

0.683

0.85

0.109

(0.68,1.30]

(0.62,1.85)

(0.55,1.16)]

(0.34,4.40)

(0.69,1.04)

4

rs642803

11:65560620

T/C

0.454

0.458

1.00

0.975

0.500

0.474

1.26

0.364

0.413

0.421

0.92

0.624

0.500

0.368

0.71

0.620

0.448

0.474

0.93

0.467

(0.73,1.36]

(0.77,2.07)

(0.66,1.29)

(0.18,2.75)

(0.77,1.13)

  1. aLD block as shown in Additional file 2: Figure S1 and S2, block 1: upstream, block 2: SLC22A11, block 3: SLC22A12, block 4: downstream. brs2078267, rs3825018 and rs476037 showed some evidence for a departure from Hardy-Weinberg equilibrium in the WP controls (P = 0.007, 0.001 and 0.006, respectively), rs2078267 in the EP/WP cases (P = 0.005) and rs476037 in the European Caucasian cases (P = 0.023). None were significant after correction for multiple testing (P <0.00042 (correction factor of 120; 10 datasets × 12 SNPs)). cBase position is according to Genome Reference Consortium human genome build 37 (GRCh37). dEffect/Other, alleles; all odds ratios (ORs) are calculated relevant to the effect allele defined as the allele in-phase with rs3825018 G allele according to 1,000 Genomes linkage-disequilibrium data. eOR, allelic OR (adjusted for sex); P, allelic asymptotic P-value. Genotyping success rate: rs475414: 97.55%; rs17299124: 94.35%; rs693591: 98.75%; rs17300741: 97.59%; rs2078267: 95.41%; rs3825018: 99.40%; rs475688: 98.75%; rs7932775: 92.40%; rs476037: 99.17%; rs478607: 98.01%; rs12289836: 97.82%; and rs642803: 97.73%. SNP, single nucleotide polymorphism; freq., frequency; Con, control.
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Arthritis Research & Therapy

ISSN: 1478-6362

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