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Table 3 Inverse-variance weighted analysis of block- 1 to -3 haplotypes

From: Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

 

European Caucasian and low ancestry Polynesianb

High ancestry Polynesianc

Polynesiand

All ancestriese

Hapa

ORf

Pf

Het Pf

ORf

Pf

Het Pf

ORf

Pf

Het Pf

ORf

Pf

Het Pf

(95% CI)

(95% CI)

(95% CI)

(95% CI)

Block 1 (rs475414|rs17299124)

C|C

0.94

0.501

0.795

0.89

0.305

0.884

0.91

0.349

0.936

0.92

0.242

0.978

(0.78,1.13)

(0.71,1.11)

(0.74,1.11)

(0.80,1.06)

T|A

1.07

0.549

0.379

0.28

6.0 × 10,4

0.512

0.50

0.006

0.120

0.56

0.103

0.007

(0.86,1.32)

(0.14,0.58)

(0.31,0.82)

(0.28,1.12)

T|C

1.02

0.848

0.584

1.30

0.022

0.914

1.29

0.019

0.965

1.14

0.093

0.572

(0.83,1.25)

(1.04,1.63)

(1.04,1.56)

(0.98,1.33)

Block 2 (rs693591|rs17300741|rs2078267)

C|A|C

0.97

0.800

0.726

1.24

0.070

0.128

1.20

0.083

0.219

1.10

0.253

0.179

(0.76,1.24)

(0.98,1.56)

(0.98,1.49)

(0.93,1.30)

G|A|C

1.08

0.468

0.842

0.78

0.037

0.446

0.83

0.083

0.368

0.94

0.440

0.204

(0.88,1.31)

(0.61,0.99)

(0.67,1.03)

(0.81,1.10)

G|G|C

,

,

,

1.35

0.093

0.369

1.31

0.113

0.509

,

,

,

(0.95,1.91)

(0.94,1.83)

G|G|T

0.97

0.706

0.682

0.57

0.022

0.797

0.69

0.042

0.600

0.91

0.252

0.316

(0.81,1.15)

(0.35,0.92)

(0.49,0.99)

(0.77,1.07)

Block 3 (rs3825018|rs475688|rs7932775|rs476037|rs478607)

A|C|T|G|A

0.82

0.040

0.953

0.76

0.035

0.272

0.77

0.024

0.451

0.80

0.004

0.594

(0.67,0.99)

(0.59,0.98)

(0.62,0.97)

(0.68,0.93)

G|C|C|G|A

1.06

0.816

0.425

1.31g

0.105

0.969

1.23g

0.183

0.543

1.22h

0.142

0.746

(0.66,1.69)

(0.95,1.81)

(0.91,1.67)

(0.94,1.60)

G|C|C|G|G

,

,

,

1.33

0.116

0.702

1.29

0.151

0.752

,

,

,

(0.93,1.90)

(0.91,1.81)

G|T|C|G|A

,

,

,

0.93

0.730

0.905

,

,

,

,

,

,

(0.63,1.39)

G|T|C|G|G

1.41

0.007

0.248

0.63

0.028

0.821

0.86

0.690

0.028

1.01

0.984

0.014

(1.10,1.82)

(0.41,0.95)

(0.41,1.80)

(0.61,1.66)

G|T|T|A|A

1.01

0.947

0.731

1.19

0.573

0.029

1.07

0.590

0.062

1.06

0.579

0.118

(0.87,1.29)

(0.75,1.36)

(0.66,2.14)

(0.84,1.36)

  1. aBlock 1 (rs475414|rs17299124), block 2 (rs693591|rs17300741|rs2078267), block 3. (rs3825018|rs475688|rs7932775|rs476037|rs478607) excluding frequency <0.01. bCombining the Eastern Polynesian (EP) low (EP(L)) and NZ European Caucasian sample sets. cCombining the EP high (EP(H)), Western Polynesian (WP) and EP/WP sample sets. dCombining the EP(H), EP(L), WP, and EP/WP sample sets. eCombining the EP(H), EP(L), WP, EP/WP and NZ European Caucasian sample sets. fOR: Inverse-variance weighted analysis odds ratio (adjusted for sex); P: inverse-variance weighted analysis P-value; Het P: heterogeneity P-value, inverse-variance weighted analyses were reanalyzed using a random-effects model if the Het P was <0.05. gEP/WP cohort was excluded from this meta-analysis owing to no female controls having the G|C|C|G|A haplotype.
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Arthritis Research & Therapy

ISSN: 1478-6362

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