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Table 4 Sample set-specific haplotype association analysis at haplotype blocks 1 to 3

From: Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

  East Polynesian (High)b East Polynesian (Low)c West Polynesian East/West Polynesian European Caucasian
Hapa Freq. ORd(95% CI) P d Freq. ORd(95% CI) P d Freq. ORd(95% CI) P d Freq. ORd(95% CI) P d Freq. ORd(95% CI) P d
Case Con Case Con Case Con Case Con Case Con
Block 1 (rs475414|rs17299124)
C|C 0.437 0.472 0.86 0.321 0.434 0.397 1.00 0.988 0.598 0.595 0.94 0.745 0.500 0.579 0.75 0.648 0.430 0.450 0.93 0.471
(0.63,1.16) (0.61,1.62) (0.67,1.34) (0.22,2.60) (0.76,1.14)
T|A 0.024 0.051 0.35 0.017 0.179 0.203 0.81 0.525 0.004 0.044 0.12 0.009 0.026 0.053 0.33 0.461 0.262 0.245 1.10 0.393
(0.15,0.83) (0.42,1.56) (0.03,0.59) (0.02,6.19) (0.88,1.38)
    1.34 0.063 0.387 0.400 1.18 0.562 0.396 0.361 1.24 0.228 0.474 0.368 1.53 0.486 0.302 0.301 1.00 0.984
T|C 0.539 0.477 (0.98,1.82)     (0.67,2.09)     (0.88,1.76)     (0.46,5.08)     (0.80,1.24)  
Block 2 (rs693591|rs17300741|rs2078267)
C|A|C 0.525 0.458 1.38 0.047 0.315 0.298 1.05 0.849 0.373 0.371 1.02 0.933 0.528 0.283 3.49 0.063 0.139 0.134 0.95 0.698
(1.00,1.90) (0.63,1.77) (0.72,1.43) (0.93,13.01) (0.72,1.25)
G|A|C 0.299 0.350 0.77 0.136 0.287 0.272 1.13 0.654 0.436 0.461 0.83 0.288 0.278 0.478 0.38 0.106 0.329 0.302 1.07 0.543
(0.54,1.09) (0.66,1.95) (0.60,1.17) (0.12,1.23) (0.87,1.32)
G|G|C 0.11 0.102 1.09 0.734 0.046 0.040 0.94 0.914 0.17 0.121 1.72 0.032 0.111 0.13 0.76 0.758 , , , ,
(0.66,1.83) (0.28,3.14) (1.05,2.83) (0.14,4.30)
G|G|T 0.061 0.090 0.56 0.070 0.352 0.381 0.87 0.607 0.019 0.043 0.50 0.117 0.083 0.109 0.93 0.932 0.525 0.556 0.98 0.830
(0.30,1.05) (0.52,1.47) (0.21,1.19) (0.19,4.68) (0.81,1.18)
Block 3 (rs3825018|rs475688|rs7932775|rs476037|rs478607)
A|C|T|G|A 0.273 0.327 0.71 0.053 0.510 0.545 0.81 0.420 0.290 0.303 0.89 0.520 0.167 0.421 0.29 0.088 0.678 0.717 0.82 0.059
(0.50,1.01) (0.48,1.36) (0.61,1.28) (0.07,1.21) (0.67,1.01)
G|C|C|G|A 0.179 0.136 1.26 0.283 0.078 0.115 0.78 0.582 0.159 0.129 1.37 0.214 0.139 0.053 , 0.997 0.035 0.024 1.19 0.534
(0.83,1.93) (0.32,1.88) (0.83,2.26) (0.68,2.08)
G|C|C|G|G 0.116 0.108 1.14 0.599 0.039 0.038 0.82 0.767 0.142 0.114 1.54 0.100 0.111 0.105 1.71 0.659 , , , ,
(0.69,1.89) (0.23,2.98) (0.92,2.59) (0.16,18.73)
G|T|C|G|A 0.057 0.068 0.84 0.574 0.000 0.016 , 0.998 0.111 0.102 1.01 0.971 0.139 0.053 0.96 0.968 , , , ,
(0.46,1.55) (0.59,1.73) (0.14,6.67)
G|T|C|G|G 0.098 0.139 0.64 0.068 0.226 0.131 2.03 0.036 0.026 0.034 0.63 0.354 0.056 0.105 0.31 0.301 0.161 0.133 1.33 0.039
(0.40,1.03) (1.05,3.95) (0.24,1.68) (0.04,2.83) (1.01,1.75)
G|T|T|A|A 0.266 0.213 1.53 0.030 0.128 0.131 0.90 0.776 0.264 0.314 0.78 0.183 0.361 0.263 2.28 0.300 0.088 0.087 1.04 0.836
(1.04,2.24) (0.44,1.85) (0.55,1.12) (0.48,10.80) (0.74,1.44)
  1. aHap, haplotypes listed in alphabetical order; those with a frequency <0.01 were excluded. bEast Polynesian (High), individuals with a STRUCTURE ancestry level ≥0.67. cEast Polynesian (Low), individuals with a STRUCTURE ancestry level <0.67. dOR, odds ratio (adjusted by sex); P: asymptomatic P-value. freq., frequency; Con, control.