Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

Flynn, Tanya J; Phipps-Green, Amanda; Hollis-Moffatt, Jade E; Merriman, Marilyn E; Topless, Ruth; Montgomery, Grant; Chapman, Brett; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R

doi:10.1186/ar4417

Table 4 Sample set-specific haplotype association analysis at haplotype blocks 1 to 3

From: Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

	East Polynesian (High)^b				East Polynesian (Low)^c				West Polynesian				East/West Polynesian				European Caucasian
Hap^a	Freq.		OR^d(95% CI)	P ^d	Freq.		OR^d(95% CI)	P ^d	Freq.		OR^d(95% CI)	P ^d	Freq.		OR^d(95% CI)	P ^d	Freq.		OR^d(95% CI)	P ^d
Hap^a	Case	Con	OR^d(95% CI)	P ^d	Case	Con	OR^d(95% CI)	P ^d	Case	Con	OR^d(95% CI)	P ^d	Case	Con	OR^d(95% CI)	P ^d	Case	Con	OR^d(95% CI)	P ^d
Block 1 (rs475414\|rs17299124)
C\|C	0.437	0.472	0.86	0.321	0.434	0.397	1.00	0.988	0.598	0.595	0.94	0.745	0.500	0.579	0.75	0.648	0.430	0.450	0.93	0.471
C\|C	0.437	0.472	(0.63,1.16)	0.321	0.434	0.397	(0.61,1.62)	0.988	0.598	0.595	(0.67,1.34)	0.745	0.500	0.579	(0.22,2.60)	0.648	0.430	0.450	(0.76,1.14)	0.471
T\|A	0.024	0.051	0.35	0.017	0.179	0.203	0.81	0.525	0.004	0.044	0.12	0.009	0.026	0.053	0.33	0.461	0.262	0.245	1.10	0.393
T\|A	0.024	0.051	(0.15,0.83)	0.017	0.179	0.203	(0.42,1.56)	0.525	0.004	0.044	(0.03,0.59)	0.009	0.026	0.053	(0.02,6.19)	0.461	0.262	0.245	(0.88,1.38)	0.393
			1.34	0.063	0.387	0.400	1.18	0.562	0.396	0.361	1.24	0.228	0.474	0.368	1.53	0.486	0.302	0.301	1.00	0.984
T\|C	0.539	0.477	(0.98,1.82)				(0.67,2.09)				(0.88,1.76)				(0.46,5.08)				(0.80,1.24)
Block 2 (rs693591\|rs17300741\|rs2078267)
C\|A\|C	0.525	0.458	1.38	0.047	0.315	0.298	1.05	0.849	0.373	0.371	1.02	0.933	0.528	0.283	3.49	0.063	0.139	0.134	0.95	0.698
C\|A\|C	0.525	0.458	(1.00,1.90)	0.047	0.315	0.298	(0.63,1.77)	0.849	0.373	0.371	(0.72,1.43)	0.933	0.528	0.283	(0.93,13.01)	0.063	0.139	0.134	(0.72,1.25)	0.698
G\|A\|C	0.299	0.350	0.77	0.136	0.287	0.272	1.13	0.654	0.436	0.461	0.83	0.288	0.278	0.478	0.38	0.106	0.329	0.302	1.07	0.543
G\|A\|C	0.299	0.350	(0.54,1.09)	0.136	0.287	0.272	(0.66,1.95)	0.654	0.436	0.461	(0.60,1.17)	0.288	0.278	0.478	(0.12,1.23)	0.106	0.329	0.302	(0.87,1.32)	0.543
G\|G\|C	0.11	0.102	1.09	0.734	0.046	0.040	0.94	0.914	0.17	0.121	1.72	0.032	0.111	0.13	0.76	0.758	,	,	,	,
G\|G\|C	0.11	0.102	(0.66,1.83)	0.734	0.046	0.040	(0.28,3.14)	0.914	0.17	0.121	(1.05,2.83)	0.032	0.111	0.13	(0.14,4.30)	0.758	,	,	,	,
G\|G\|T	0.061	0.090	0.56	0.070	0.352	0.381	0.87	0.607	0.019	0.043	0.50	0.117	0.083	0.109	0.93	0.932	0.525	0.556	0.98	0.830
G\|G\|T	0.061	0.090	(0.30,1.05)	0.070	0.352	0.381	(0.52,1.47)	0.607	0.019	0.043	(0.21,1.19)	0.117	0.083	0.109	(0.19,4.68)	0.932	0.525	0.556	(0.81,1.18)	0.830
Block 3 (rs3825018\|rs475688\|rs7932775\|rs476037\|rs478607)
A\|C\|T\|G\|A	0.273	0.327	0.71	0.053	0.510	0.545	0.81	0.420	0.290	0.303	0.89	0.520	0.167	0.421	0.29	0.088	0.678	0.717	0.82	0.059
A\|C\|T\|G\|A	0.273	0.327	(0.50,1.01)	0.053	0.510	0.545	(0.48,1.36)	0.420	0.290	0.303	(0.61,1.28)	0.520	0.167	0.421	(0.07,1.21)	0.088	0.678	0.717	(0.67,1.01)	0.059
G\|C\|C\|G\|A	0.179	0.136	1.26	0.283	0.078	0.115	0.78	0.582	0.159	0.129	1.37	0.214	0.139	0.053	,	0.997	0.035	0.024	1.19	0.534
G\|C\|C\|G\|A	0.179	0.136	(0.83,1.93)	0.283	0.078	0.115	(0.32,1.88)	0.582	0.159	0.129	(0.83,2.26)	0.214	0.139	0.053	,	0.997	0.035	0.024	(0.68,2.08)	0.534
G\|C\|C\|G\|G	0.116	0.108	1.14	0.599	0.039	0.038	0.82	0.767	0.142	0.114	1.54	0.100	0.111	0.105	1.71	0.659	,	,	,	,
G\|C\|C\|G\|G	0.116	0.108	(0.69,1.89)	0.599	0.039	0.038	(0.23,2.98)	0.767	0.142	0.114	(0.92,2.59)	0.100	0.111	0.105	(0.16,18.73)	0.659	,	,	,	,
G\|T\|C\|G\|A	0.057	0.068	0.84	0.574	0.000	0.016	,	0.998	0.111	0.102	1.01	0.971	0.139	0.053	0.96	0.968	,	,	,	,
G\|T\|C\|G\|A	0.057	0.068	(0.46,1.55)	0.574	0.000	0.016	,	0.998	0.111	0.102	(0.59,1.73)	0.971	0.139	0.053	(0.14,6.67)	0.968	,	,	,	,
G\|T\|C\|G\|G	0.098	0.139	0.64	0.068	0.226	0.131	2.03	0.036	0.026	0.034	0.63	0.354	0.056	0.105	0.31	0.301	0.161	0.133	1.33	0.039
G\|T\|C\|G\|G	0.098	0.139	(0.40,1.03)	0.068	0.226	0.131	(1.05,3.95)	0.036	0.026	0.034	(0.24,1.68)	0.354	0.056	0.105	(0.04,2.83)	0.301	0.161	0.133	(1.01,1.75)	0.039
G\|T\|T\|A\|A	0.266	0.213	1.53	0.030	0.128	0.131	0.90	0.776	0.264	0.314	0.78	0.183	0.361	0.263	2.28	0.300	0.088	0.087	1.04	0.836
G\|T\|T\|A\|A	0.266	0.213	(1.04,2.24)	0.030	0.128	0.131	(0.44,1.85)	0.776	0.264	0.314	(0.55,1.12)	0.183	0.361	0.263	(0.48,10.80)	0.300	0.088	0.087	(0.74,1.44)	0.836

^aHap, haplotypes listed in alphabetical order; those with a frequency <0.01 were excluded. ^bEast Polynesian (High), individuals with a STRUCTURE ancestry level ≥0.67. ^cEast Polynesian (Low), individuals with a STRUCTURE ancestry level <0.67. ^dOR, odds ratio (adjusted by sex); P: asymptomatic P-value. freq., frequency; Con, control.

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