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Table 2 Beneficial and detrimental effects of Core Set and ACR20 on trials in rheumatoid arthritis

From: The ACR20 and defining a threshold for response in rheumatic diseases: too much of a good thing

Beneficial effects Detrimental effects
Selected outcome measures most likely to change with treatment Dichotomized a continuous measures of response
Made uniform trial outcome measures across studies, making comparisons possible  
Decreased the number of outcomes from >10 to 7 and then to 1 (ACR20)