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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction

Figure 5

Th17 cells contribute to fibroblast proliferation and collage production. (A) Fibroblasts were stimulated for 48 hours with supernatants from cultures of PI-stimulated Th17 cells from patients with active SSc (Active) or healthy controls (Control) in the presence or absence of IL-17-neutralizing antibody, and the gene expression of collagen 1 and collagen 3 was analyzed with real-time RT-PCR analysis (n = 5 for each group). (B) Fibroblasts were stimulated for 48 hours with supernatants from cultures of PI-stimulated Th17 cells from patients with active SSc (Active) or healthy controls (Control) in the presence or absence of IL-17-neutralizing antibody, and the levels of collagen 1 and collagen 3 in the supernatants were determined with ELISA (n = 5 for each group).

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