Table 2 Biomarkers in patients with and without ultrasound-defined synovitis
All (n = 55) | Ultrasound-defined active synovitis | P valuea | ||
|---|---|---|---|---|
Yes (n = 25) | No (n = 30) | |||
Activin A | 6,556 (3,012 to 10,887) | 9,186 (4,846 to 12,297) | 4,175 (2,450 to 10,255) | 0.086 |
ANG | 7,670 (6,206 to 10,496) | 8,009 (6,729 to 10,816) | 6867 (5,861 to 9,421) | 0.119 |
ANG-1 | 32,622 (28,287 to 36,705) | 34,343 (28,615 to 39,515) | 31,066 (27,977 to 35,834) | 0.210 |
ANG-2 | 726.4 (595.8-1014.8) | 881 (670 to 1,072) | 702 (536 to 869) | 0.038 |
Angiostatin | 37,409 (30,333 to 48,183) | 34,326 (28,123 to 46,416) | 39,648 (34,243 to 49,152) | 0.111 |
ANGPTL4 | 15,120 (6,450 to 6,464) | 1,374 (606 to 6,030) | 2,294 (7,450 to 7,713) | 0.630 |
bFGF | 314 (268 to 492) | 384 (288 to 675) | 295 (265 to 318) | 0.007 |
CXCL16 | 849 (739 to 1,311) | 907 (774 to 1,214) | 848 (682 to 1,454) | 0.967 |
ENA-78 | 1,186 (813 to 1,746) | 1,146 (871 to 1,664) | 1,241 (780 to 1,886) | 0.927 |
GRO | 9,570 (7,592 to 12,000) | 10,724 (8,644 to 12,000) | 9,284 (7,050 to 12,000) | 0.350 |
IL-17 | 10 (0 to 27) | 13 (5 to 32) | 7 (0 to 25) | 0.141 |
IL-17 F | 288 (57 to 4,888) | 344 (59 to 3,351) | 204 (58 to 4,980) | 0.872 |
IL-18 | 589 (395 to 1,066) | 741 (463 to 1,224) | 514 (341 to 890) | 0.066 |
IL-20 | 259 (92 to 836) | 422 (145 to 924) | 234 (68 to 727) | 0.098 |
IL-23 | 249 (176 to 431) | 257 (219 to 699) | 240 (166 to 323) | 0.098 |
IL-33 | 14 (4 to 73) | 17 (4 to 69) | 11 (4 to 83) | 0.866 |
IL-6 | 149 (93 to 290) | 177 (106 to 317) | 136 (91 to 226) | 0.136 |
IL-8 | 30 (21 to 62) | 42 (21 to 64) | 26 (22 to 46) | 0.366 |
MMP-2 | 2,738 (1,941 to 4,050) | 3,762 (2,294 to 5,574) | 2,404 (1,915 to 3,263) | 0.027 |
MMP-9 | 28,180 (21,104 to 34,808) | 27,370 (23,526 to 34,009) | 29,008 (17,682 to 35,779) | 0.940 |
PlGF | 288 (148 to 979) | 453 (192 to 1,357) | 237 (117 to 721) | 0.043 |
SDF-1 | 280 (117 to 1,554) | 750 (164 to 3,305) | 165 (84 to 1,006) | 0.035 |
TGF-β1 | 1,453 (809 to 2,252) | 1,741 (1,065 to 2,424) | 1,196 (649 to 2,053) | 0.089 |
Tie-1 | 5,099 (1,647 to 19,737) | 6,841 (1,896 to 31,161) | 4,039 (1,556 to 12,210) | 0.112 |
Tie-2 | 14,735 (6,215 to 32,401) | 20,559 (7,426 to 47,483) | 11,436 (4,101 to 26,744) | 0.317 |
TNFα | 6,755 (4,460 to 12,112) | 6,755 (4,539 to 12,869) | 6,362 (4,379 to 10,507) | 0.465 |
VEGF | 1,193 (815 to 1,990) | 1,193 (871 to 2,178) | 1,193 (810 to 1,911) | 0.609 |
VEGFR-1 | 485 (308 to 881) | 634 (366 to 1,001) | 471 (278 to 723) | 0.204 |
VEGFR-2 | 1,014 (713 to 1,918) | 1,096 (869 to 1,807) | 1,005 (679 to 1,937) | 0.149 |
VEGF-D | 32,097 (17,815 to 227,618) | 63,480 (26,776 to 600,000) | 27,545 (12,517 to 76,119) | 0.018 |