TY - JOUR AU - Adães, Sara AU - Mendonça, Marcelo AU - Santos, Telmo N. AU - Castro-Lopes, José M. AU - Ferreira-Gomes, Joana AU - Neto, Fani L. PY - 2014 DA - 2014/01/15 TI - Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis JO - Arthritis Research & Therapy SP - R10 VL - 16 IS - 1 AB - Animal models currently used in osteoarthritis-associated pain research inadequately reproduce the initiating events and structural pathology of human osteoarthritis. Conversely, intra-articular injection of collagenase is a structurally relevant model, as it induces articular degeneration both by digesting collagen from cartilage and by causing articular instability, thereby reproducing some of the main events associated with osteoarthritis onset and development. Here, we evaluated if the intra-articular injection of collagenase can be an alternative model to study nociception associated with osteoarthritis. SN - 1478-6362 UR - https://doi.org/10.1186/ar4436 DO - 10.1186/ar4436 ID - Adães2014 ER -