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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

Figure 3

Cathepsin and matrix metalloprotease activity were decreased in Indian hedgehog–deleted mice 2 months after partial medial meniscectomy. Representative images produced with ProSense (A) and MMPSense (B) fluorescent imaging agents (top panels) and summary results (bottom panels) are shown. Data are means ± SD. No tamoxifen–partial medial meniscectomy (TM-PMM), n = 12; TM-PMM, n = 8; and TM-sham, n = 3. *P = 0.016, #P = 0.042.

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Arthritis Research & Therapy

ISSN: 1478-6362

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