TY - JOUR AU - Seegobin, Seth D. AU - Ma, Margaret HY AU - Dahanayake, Chanaka AU - Cope, Andrew P. AU - Scott, David L. AU - Lewis, Cathryn M. AU - Scott, Ian C. PY - 2014 DA - 2014/01/16 TI - ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial JO - Arthritis Research & Therapy SP - R13 VL - 16 IS - 1 AB - UK guidelines recommend that all early active rheumatoid arthritis (RA) patients are offered combination disease-modifying antirheumatic drugs (DMARDs) and short-term corticosteroids. Anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA may differ in their treatment responses. We used data from a randomized controlled trial - the Combination Anti-Rheumatic Drugs in Early RA (CARDERA) trial - to examine whether responses to intensive combination treatments in early RA differ by ACPA status. SN - 1478-6362 UR - https://doi.org/10.1186/ar4439 DO - 10.1186/ar4439 ID - Seegobin2014 ER -