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Table 3 Treatment effects on mean changes in Larsen and DAS28 scores in ACPA-positive and ACPA-negative RA

From: ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial

  Time Ciclosporin Prednisolone Triple vs. monotherapy
Ciclosporin Placebo P Prednisolone Placebo P Triple Mono P
Larsen
ACPA+ 6 1.60 (0.37) 2.74 (0.44) 0.047 1.44 (0.22) 2.85 (0.53) 0.015 1.25 (0.28) 3.86 (0.80) 0.003
12 3.09 (0.47) 4.81 (0.61) 0.027 2.58 (0.35) 5.26 (0.67) 0.001 2.41 (0.52) 6.92 (1.10) <0.001
18 3.97 (0.53) 6.43 (0.78) 0.010 3.79 (0.48) 6.52 (0.80) 0.004 3.20 (0.66) 8.52 (1.39) 0.001
24 4.32 (0.58) 7.53 (0.84) 0.002 4.57 (0.57) 7.15 (0.84) 0.012 3.66 (0.70) 9.58 (1.41) <0.001
ACPA- 6 0.72 (0.30) 1.25 (0.36) 0.270 0.67 (0.29) 1.30 (0.37) 0.182 0.48 (0.35) 1.60 (0.55) 0.093
12 2.54 (1.11) 2.17 (0.59) 0.770 1.86 (0.58) 2.79 (1.04) 0.435 1.36 (0.47) 2.03 (0.66) 0.409
18 2.97 (1.30) 2.33 (0.60) 0.660 1.86 (0.56) 3.33 (1.21) 0.275 1.66 (0.64) 2.57 (0.79) 0.388
24 3.11 (1.32) 2.56 (0.61) 0.704 2.04 (0.60) 3.52 (1.22) 0.277 1.70 (0.69) 2.72 (0.77) 0.335
DAS28
ACPA+ 6 -1.61 (0.12) -1.49 (0.13) 0.488 -1.97 (0.12) -1.13 (0.11) <0.001 -1.98 (0.18) -0.99 (0.17) <0.001
12 -1.46 (0.12) -1.19 (0.14) 0.147 -1.36 (0.13) -1.29 (0.13) 0.716 -1.48 (0.18) -1.14 (0.19) 0.190
18 -1.49 (0.13) -1.36 (0.14) 0.498 -1.50 (0.14) -1.36 (0.13) 0.479 -1.64 (0.20) -1.37 (0.20) 0.356
24 -1.62 (0.13) -1.38 (0.15) 0.211 -1.62 (0.14) -1.38 (0.14) 0.203 -1.84 (0.19) -1.36 (0.22) 0.087
ACPA- 6 -1.02 (0.21) -1.42 (0.20) 0.173 -1.47 (0.24) -1.00 (0.17) 0.111 -1.43 (0.33) -1.32 (0.22) 0.792
12 -0.94 (0.21) -1.32 (0.21) 0.209 -1.01 (0.21) -1.25 (0.21) 0.421 -0.73 (0.33) -1.36 (0.33) 0.186
18 -1.33 (0.24) -1.52 (0.20) 0.552 -1.33 (0.23) -1.51 (0.22) 0.579 -1.27 (0.37) -1.62 (0.30) 0.462
24 -1.16 (0.22) -1.49 (0.20) 0.256 -1.32 (0.20) -1.34 (0.21) 0.960 -1.27 (0.32) -1.59 (0.30) 0.464
  1. Data are mean changes (SE) unless otherwise stated; P = P-values from t-tests; Triple = triple DMARD therapy; Mono = monotherapy with methotrexate; time is in months. ACPA, anti-citrullinated protein antibody; DAS28, disease activity scores on a 28-joint count.