Table 3 Treatment effects on mean changes in Larsen and DAS28 scores in ACPA-positive and ACPA-negative RA

Larsen

ACPA+

6

1.60 (0.37)

2.74 (0.44)

0.047

1.44 (0.22)

2.85 (0.53)

0.015

1.25 (0.28)

3.86 (0.80)

0.003

12

3.09 (0.47)

4.81 (0.61)

0.027

2.58 (0.35)

5.26 (0.67)

0.001

2.41 (0.52)

6.92 (1.10)

<0.001

18

3.97 (0.53)

6.43 (0.78)

0.010

3.79 (0.48)

6.52 (0.80)

0.004

3.20 (0.66)

8.52 (1.39)

0.001

24

4.32 (0.58)

7.53 (0.84)

0.002

4.57 (0.57)

7.15 (0.84)

0.012

3.66 (0.70)

9.58 (1.41)

<0.001

ACPA-

6

0.72 (0.30)

1.25 (0.36)

0.270

0.67 (0.29)

1.30 (0.37)

0.182

0.48 (0.35)

1.60 (0.55)

0.093

12

2.54 (1.11)

2.17 (0.59)

0.770

1.86 (0.58)

2.79 (1.04)

0.435

1.36 (0.47)

2.03 (0.66)

0.409

18

2.97 (1.30)

2.33 (0.60)

0.660

1.86 (0.56)

3.33 (1.21)

0.275

1.66 (0.64)

2.57 (0.79)

0.388

24

3.11 (1.32)

2.56 (0.61)

0.704

2.04 (0.60)

3.52 (1.22)

0.277

1.70 (0.69)

2.72 (0.77)

0.335

DAS28

ACPA+

6

-1.61 (0.12)

-1.49 (0.13)

0.488

-1.97 (0.12)

-1.13 (0.11)

<0.001

-1.98 (0.18)

-0.99 (0.17)

<0.001

12

-1.46 (0.12)

-1.19 (0.14)

0.147

-1.36 (0.13)

-1.29 (0.13)

0.716

-1.48 (0.18)

-1.14 (0.19)

0.190

18

-1.49 (0.13)

-1.36 (0.14)

0.498

-1.50 (0.14)

-1.36 (0.13)

0.479

-1.64 (0.20)

-1.37 (0.20)

0.356

24

-1.62 (0.13)

-1.38 (0.15)

0.211

-1.62 (0.14)

-1.38 (0.14)

0.203

-1.84 (0.19)

-1.36 (0.22)

0.087

ACPA-

6

-1.02 (0.21)

-1.42 (0.20)

0.173

-1.47 (0.24)

-1.00 (0.17)

0.111

-1.43 (0.33)

-1.32 (0.22)

0.792

12

-0.94 (0.21)

-1.32 (0.21)

0.209

-1.01 (0.21)

-1.25 (0.21)

0.421

-0.73 (0.33)

-1.36 (0.33)

0.186

18

-1.33 (0.24)

-1.52 (0.20)

0.552

-1.33 (0.23)

-1.51 (0.22)

0.579

-1.27 (0.37)

-1.62 (0.30)

0.462

24

-1.16 (0.22)

-1.49 (0.20)

0.256

-1.32 (0.20)

-1.34 (0.21)

0.960

-1.27 (0.32)

-1.59 (0.30)

0.464