Skip to main content

Table 4 Treatment effects on mean changes in EuroQol and PCS scores in ACPA-positive and ACPA-negative RA

From: ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial

  

Ciclosporin

Prednisolone

Triple vs. monotherapy

Time

Ciclosporin

Placebo

P

Prednisolone

Placebo

P

Triple

Mono

P

EuroQol

ACPA+

6

0.16 (0.02)

0.16 (0.02)

0.978

0.21 (0.02)

0.11 (0.02)

0.001

0.21 (0.03)

0.11 (0.04)

0.029

12

0.16 (0.02)

0.09 (0.03)

0.044

0.14 (0.02)

0.12 (0.02)

0.481

0.19 (0.03)

0.10 (0.04)

0.063

18

0.15 (0.02)

0.11 (0.03)

0.215

0.14 (0.03)

0.13 (0.02)

0.651

0.18 (0.04)

0.12 (0.04)

0.267

24

0.17 (0.02)

0.12 (0.03)

0.176

0.16 (0.03)

0.13 (0.02)

0.403

0.20 (0.04)

0.12 (0.04)

0.152

ACPA-

6

0.08 (0.04)

0.09 (0.04)

0.876

0.16 (0.04)

0.02 (0.04)

0.011

0.19 (0.06)

0.05 (0.05)

0.074

12

0.08 (0.04)

0.06 (0.04)

0.756

0.14 (0.04)

0.01 (0.04)

0.033

0.14 (0.05)

0.00 (0.05)

0.057

18

0.10 (0.04)

0.09 (0.04)

0.776

0.16 (0.04)

0.03 (0.04)

0.036

0.19 (0.06)

0.05 (0.05)

0.058

24

0.10 (0.04)

0.09 (0.04)

0.908

0.16 (0.04)

0.04 (0.04)

0.035

0.21 (0.05)

0.08 (0.05)

0.057

PCS

ACPA+

6

7.96 (0.89)

5.15 (0.95)

0.031

9.15 (0.96)

4.01 (0.83)

<0.001

10.42 (1.30)

2.29 (1.16)

<0.001

12

5.27 (0.84)

4.17 (0.94)

0.380

6.04 (0.93)

3.42 (0.84)

0.037

7.05 (1.23)

3.28 (1.27)

0.035

18

6.11 (0.89)

3.87 (1.02)

0.097

5.51 (1.01)

4.53 (0.89)

0.472

7.77 (1.39)

4.58 (1.44)

0.114

24

5.77 (0.96)

4.91 (1.03)

0.544

6.36 (1.03)

4.34 (0.95)

0.150

8.33 (1.46)

5.53 (1.49)

0.180

ACPA-

6

2.64 (1.41)

4.04 (1.21)

0.449

4.14 (1.31)

2.68 (1.29)

0.428

4.86 (2.11)

4.54 (1.78)

0.908

12

3.27 (1.35)

4.93 (1.15)

0.349

3.70 (1.25)

4.52 (1.25)

0.646

3.25 (2.07)

5.61 (1.76)

0.386

18

3.86 (1.38)

5.06 (1.24)

0.516

4.41 (1.40)

4.55 (1.23)

0.937

4.72 (2.11)

5.88 (1.67)

0.664

24

4.65 (1.69)

5.17 (1.07)

0.793

5.51 (1.58)

4.40 (1.21)

0.575

7.44 (2.70)

6.48 (1.36)

0.753

  1. Data are mean changes (SE) unless otherwise stated; P = P-values from t-tests; Triple = triple DMARD therapy; Mono = monotherapy with methotrexate; time is in months. ACPA, anti-citrullinated protein antibody; PCS, physical component summary.