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Table 4 Treatment effects on mean changes in EuroQol and PCS scores in ACPA-positive and ACPA-negative RA

From: ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial

   Ciclosporin Prednisolone Triple vs. monotherapy
Time Ciclosporin Placebo P Prednisolone Placebo P Triple Mono P
EuroQol
ACPA+ 6 0.16 (0.02) 0.16 (0.02) 0.978 0.21 (0.02) 0.11 (0.02) 0.001 0.21 (0.03) 0.11 (0.04) 0.029
12 0.16 (0.02) 0.09 (0.03) 0.044 0.14 (0.02) 0.12 (0.02) 0.481 0.19 (0.03) 0.10 (0.04) 0.063
18 0.15 (0.02) 0.11 (0.03) 0.215 0.14 (0.03) 0.13 (0.02) 0.651 0.18 (0.04) 0.12 (0.04) 0.267
24 0.17 (0.02) 0.12 (0.03) 0.176 0.16 (0.03) 0.13 (0.02) 0.403 0.20 (0.04) 0.12 (0.04) 0.152
ACPA- 6 0.08 (0.04) 0.09 (0.04) 0.876 0.16 (0.04) 0.02 (0.04) 0.011 0.19 (0.06) 0.05 (0.05) 0.074
12 0.08 (0.04) 0.06 (0.04) 0.756 0.14 (0.04) 0.01 (0.04) 0.033 0.14 (0.05) 0.00 (0.05) 0.057
18 0.10 (0.04) 0.09 (0.04) 0.776 0.16 (0.04) 0.03 (0.04) 0.036 0.19 (0.06) 0.05 (0.05) 0.058
24 0.10 (0.04) 0.09 (0.04) 0.908 0.16 (0.04) 0.04 (0.04) 0.035 0.21 (0.05) 0.08 (0.05) 0.057
PCS
ACPA+ 6 7.96 (0.89) 5.15 (0.95) 0.031 9.15 (0.96) 4.01 (0.83) <0.001 10.42 (1.30) 2.29 (1.16) <0.001
12 5.27 (0.84) 4.17 (0.94) 0.380 6.04 (0.93) 3.42 (0.84) 0.037 7.05 (1.23) 3.28 (1.27) 0.035
18 6.11 (0.89) 3.87 (1.02) 0.097 5.51 (1.01) 4.53 (0.89) 0.472 7.77 (1.39) 4.58 (1.44) 0.114
24 5.77 (0.96) 4.91 (1.03) 0.544 6.36 (1.03) 4.34 (0.95) 0.150 8.33 (1.46) 5.53 (1.49) 0.180
ACPA- 6 2.64 (1.41) 4.04 (1.21) 0.449 4.14 (1.31) 2.68 (1.29) 0.428 4.86 (2.11) 4.54 (1.78) 0.908
12 3.27 (1.35) 4.93 (1.15) 0.349 3.70 (1.25) 4.52 (1.25) 0.646 3.25 (2.07) 5.61 (1.76) 0.386
18 3.86 (1.38) 5.06 (1.24) 0.516 4.41 (1.40) 4.55 (1.23) 0.937 4.72 (2.11) 5.88 (1.67) 0.664
24 4.65 (1.69) 5.17 (1.07) 0.793 5.51 (1.58) 4.40 (1.21) 0.575 7.44 (2.70) 6.48 (1.36) 0.753
  1. Data are mean changes (SE) unless otherwise stated; P = P-values from t-tests; Triple = triple DMARD therapy; Mono = monotherapy with methotrexate; time is in months. ACPA, anti-citrullinated protein antibody; PCS, physical component summary.