|  | Ciclosporin | Prednisolone | Triple vs. monotherapy | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Time | Ciclosporin | Placebo | P | Prednisolone | Placebo | P | Triple | Mono | P | |
EuroQol | ||||||||||
ACPA+ | 6 | 0.16 (0.02) | 0.16 (0.02) | 0.978 | 0.21 (0.02) | 0.11 (0.02) | 0.001 | 0.21 (0.03) | 0.11 (0.04) | 0.029 |
12 | 0.16 (0.02) | 0.09 (0.03) | 0.044 | 0.14 (0.02) | 0.12 (0.02) | 0.481 | 0.19 (0.03) | 0.10 (0.04) | 0.063 | |
18 | 0.15 (0.02) | 0.11 (0.03) | 0.215 | 0.14 (0.03) | 0.13 (0.02) | 0.651 | 0.18 (0.04) | 0.12 (0.04) | 0.267 | |
24 | 0.17 (0.02) | 0.12 (0.03) | 0.176 | 0.16 (0.03) | 0.13 (0.02) | 0.403 | 0.20 (0.04) | 0.12 (0.04) | 0.152 | |
ACPA- | 6 | 0.08 (0.04) | 0.09 (0.04) | 0.876 | 0.16 (0.04) | 0.02 (0.04) | 0.011 | 0.19 (0.06) | 0.05 (0.05) | 0.074 |
12 | 0.08 (0.04) | 0.06 (0.04) | 0.756 | 0.14 (0.04) | 0.01 (0.04) | 0.033 | 0.14 (0.05) | 0.00 (0.05) | 0.057 | |
18 | 0.10 (0.04) | 0.09 (0.04) | 0.776 | 0.16 (0.04) | 0.03 (0.04) | 0.036 | 0.19 (0.06) | 0.05 (0.05) | 0.058 | |
24 | 0.10 (0.04) | 0.09 (0.04) | 0.908 | 0.16 (0.04) | 0.04 (0.04) | 0.035 | 0.21 (0.05) | 0.08 (0.05) | 0.057 | |
PCS | ||||||||||
ACPA+ | 6 | 7.96 (0.89) | 5.15 (0.95) | 0.031 | 9.15 (0.96) | 4.01 (0.83) | <0.001 | 10.42 (1.30) | 2.29 (1.16) | <0.001 |
12 | 5.27 (0.84) | 4.17 (0.94) | 0.380 | 6.04 (0.93) | 3.42 (0.84) | 0.037 | 7.05 (1.23) | 3.28 (1.27) | 0.035 | |
18 | 6.11 (0.89) | 3.87 (1.02) | 0.097 | 5.51 (1.01) | 4.53 (0.89) | 0.472 | 7.77 (1.39) | 4.58 (1.44) | 0.114 | |
24 | 5.77 (0.96) | 4.91 (1.03) | 0.544 | 6.36 (1.03) | 4.34 (0.95) | 0.150 | 8.33 (1.46) | 5.53 (1.49) | 0.180 | |
ACPA- | 6 | 2.64 (1.41) | 4.04 (1.21) | 0.449 | 4.14 (1.31) | 2.68 (1.29) | 0.428 | 4.86 (2.11) | 4.54 (1.78) | 0.908 |
12 | 3.27 (1.35) | 4.93 (1.15) | 0.349 | 3.70 (1.25) | 4.52 (1.25) | 0.646 | 3.25 (2.07) | 5.61 (1.76) | 0.386 | |
18 | 3.86 (1.38) | 5.06 (1.24) | 0.516 | 4.41 (1.40) | 4.55 (1.23) | 0.937 | 4.72 (2.11) | 5.88 (1.67) | 0.664 | |
24 | 4.65 (1.69) | 5.17 (1.07) | 0.793 | 5.51 (1.58) | 4.40 (1.21) | 0.575 | 7.44 (2.70) | 6.48 (1.36) | 0.753 |