Examples of typical blood B-cell subset profiling by flow cytometry. All analyses are gated on CD19+ B cells. A ratio is computed between Bm2 + Bm2′ (immunoglobulin (Ig)D+/CD38low-high population) and eBm5 + Bm5 (IgD-/CD38low-negative population) subset proportions. (a) Primary Sjögren’s syndrome patient, with a ratio of 17.9. (b) Idiopathic sicca patient, with a ratio of 2.2.