Table 2 Diagnostic value of the biological items
From: Diagnostic accuracy of blood B-cell subset profiling and autoimmunity markers in Sjögren’s syndrome
Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
Anti-SSA or -SSB positivity | 61.0% | 100% | 100% | 79.9% |
Anti-SSA positivity | 61.0% | 100% | 100% | 79.9% |
Anti-SSB positivity | 32.5% | 100% | 100% | 66.7% |
ANA ≥1:320 | 80.5% | 58.7% | 59.0% | 80.3% |
ANA ≥1:640 | 70.1% | 81.7% | 74.0% | 78.7% |
IgM-RF positivity | 45.5% | 79.8% | 62.5% | 66.4% |
IgA-RF positivity | 41.6% | 95.2% | 86.5% | 68.8% |
Gammaglobulins ≥14 g/L | 46.8% | 92.3% | 81.8% | 70.1% |
IgG ≥14 g/L | 49.4% | 91.3% | 80.9% | 70.9% |
B-cell ratio ≥5 | 53.2% | 82.7% | 69.5% | 70.5% |
ACR criteria serologic item | 63.6% | 93.7% | 87.5% | 77.6% |