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Table 2 Diagnostic value of the biological items

From: Diagnostic accuracy of blood B-cell subset profiling and autoimmunity markers in Sjögren’s syndrome

  Sensitivity Specificity PPV NPV
Anti-SSA or -SSB positivity 61.0% 100% 100% 79.9%
Anti-SSA positivity 61.0% 100% 100% 79.9%
Anti-SSB positivity 32.5% 100% 100% 66.7%
ANA ≥1:320 80.5% 58.7% 59.0% 80.3%
ANA ≥1:640 70.1% 81.7% 74.0% 78.7%
IgM-RF positivity 45.5% 79.8% 62.5% 66.4%
IgA-RF positivity 41.6% 95.2% 86.5% 68.8%
Gammaglobulins ≥14 g/L 46.8% 92.3% 81.8% 70.1%
IgG ≥14 g/L 49.4% 91.3% 80.9% 70.9%
B-cell ratio ≥5 53.2% 82.7% 69.5% 70.5%
ACR criteria serologic item 63.6% 93.7% 87.5% 77.6%
  1. PPV, positive predictive value; NPV, negative predictive value; ANA, antinuclear antibodies; Ig, immunoglobulin; RF, rheumatoid factor; American College of Rheumatology (ACR) criteria serologic item: (anti-SSA/B or (ANA ≥1:320 + IgM-RF)).