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Table 4 JKOM score and percentage change of JKOM score by K/L grade subgroup

From: Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial

  JKOM score % change of JKOM score
   Mean SD P(post vs. pre) Mean (%) SD Difference (%) [IA-HA - NSAID] (95% CI)
K/L grade 1
IA-HA (n = 15) Pre-treatment 24.8 13.0 0.058 -9.3 78.0 25.7 (-19.3 to 70.7)
Post-treatment 18.7 12.6
NSAID (n = 14) Pre-treatment 35.9 15.4 0.001 -34.9 26.0
Post-treatment 23.4 15.7
K/L grade 2
IA-HA (n = 48) Pre-treatment 33.1 14.7 <0.001 -43.8 27.1 -9.2 (-24.4 to 6.0)
Post-treatment 18.8 12.6
NSAID (n = 45) Pre-treatment 30.8 13.9 <0.001 -34.6 44.9
Post-treatment 20.4 14.5
K/L grade 3
IA-HA (n = 35) Pre-treatment 38.6 17.1 <0.001 -33.1 23.6 -6.2 (-21.6 to 9.3)
Post-treatment 26.4 16.9
NSAID (n = 27) Pre-treatment 31.9 13.6 0.003 -26.9 37.0
  Post-treatment 23.7 17.3     
  1. A P value less than 0.05 was considered to be significant. JKOM, Japanese Knee Osteoarthritis Measure; IA, intra-articular; HA, hyaluronic acid; NSAID, non-steroidal anti-inflammatory drug; K/L, Kellgren-Laurence grade.