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Table 4 JKOM score and percentage change of JKOM score by K/L grade subgroup

From: Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial

 

JKOM score

% change of JKOM score

  

Mean

SD

P(post vs. pre)

Mean (%)

SD

Difference (%) [IA-HA - NSAID] (95% CI)

K/L grade 1

IA-HA (n = 15)

Pre-treatment

24.8

13.0

0.058

-9.3

78.0

25.7 (-19.3 to 70.7)

Post-treatment

18.7

12.6

NSAID (n = 14)

Pre-treatment

35.9

15.4

0.001

-34.9

26.0

Post-treatment

23.4

15.7

K/L grade 2

IA-HA (n = 48)

Pre-treatment

33.1

14.7

<0.001

-43.8

27.1

-9.2 (-24.4 to 6.0)

Post-treatment

18.8

12.6

NSAID (n = 45)

Pre-treatment

30.8

13.9

<0.001

-34.6

44.9

Post-treatment

20.4

14.5

K/L grade 3

IA-HA (n = 35)

Pre-treatment

38.6

17.1

<0.001

-33.1

23.6

-6.2 (-21.6 to 9.3)

Post-treatment

26.4

16.9

NSAID (n = 27)

Pre-treatment

31.9

13.6

0.003

-26.9

37.0

 

Post-treatment

23.7

17.3

    
  1. A P value less than 0.05 was considered to be significant. JKOM, Japanese Knee Osteoarthritis Measure; IA, intra-articular; HA, hyaluronic acid; NSAID, non-steroidal anti-inflammatory drug; K/L, Kellgren-Laurence grade.