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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus

Figure 2

Correlation of IFN score, STAT1, ADAR, CCL2, CXCL10, and miR-146a levels to anti-double-strandard DNA (dsDNA) autoantibodies. (A) Systemic lupus erythematosus disease activity (SLEDAI) scores were significantly higher in anti-dsDNA(+) than anti-dsDNA(−) patient visits. (B, C) C3 and C4 were significantly lower in anti-dsDNA(+) than in anti-dsDNA(−) patients. (D) IFN score, (E) STAT1, (F) ADAR, (G) CCL2, and (H) CXCL10 were significantly elevated in SLE patient visits compared to healthy donors (HD), but no statistical differences were detected between anti-dsDNA(+) and anti-dsDNA(−) patients for IFN score, ADAR, or CXCL10. (I-K) TNFα, pri-miR-146a, and miR-146a did not show any significant difference among the groups. STAT, signal transducers and activators of transcription; ADAR, adenosine deaminase acting on RNA; CCL2, C-C motif chemokine ligand 2; CXCL10, C-X-C motif chemokine 10.

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