Effect of high versus low STAT1 expression in ADAR, CCL2, and CXCL10 correlation with IFN score. (A) ADAR, (B) CCL2, and (C) CXCL10 displayed a significant linear coefficient of determination (r2) with IFN score for high STAT1 (HS, blue, left panels). For the SLE patient visits with low STAT1 (LS, red, left panels) r2 resembled that of the LS healthy donors (HD) (black, right panels). (B, C) The slopes of high STAT1 for CCL2 and CXCL10 were significantly higher than those for patient visits with low STAT1 (left panels). ADAR, adenosine deaminase acting on RNA; CCL2, C-C motif chemokine ligand 2; CXCL10, C-X-C motif chemokine 10.