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Table 2 Effects of treatments on vascular reactivity in animal model of arthritis

From: Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

Authors (year) Animal strain Arthritis model Arthritogenetic agent( injection zone) Treatment Vascular reactivity Arthritis severity
Cinar et al. [15] (1998) Male rat (strain NR) AIA M. tuberculosis (pad) Vitamin E 100 mg/kg per day (im) from day 0 to day 26 post-injection ↓ ACh, ↑ PE
Ulker et al. [16] (2000) Male Wistar rat AIA M. tuberculosis (pad) Nabumetone 120 and 240 mg/kg per day (po) from day 14 to day 28 post-injection Normalization of responses to Ach and SNP = (120 mg/kg per day) ↓ (240 mg/kg per day)
Can et al. [17] (2002) Male Wistar rat AIA M. tuberculosis (pad) Vitamin E 100 mg/kg per day (im) from day 0 to day 26 post-injection ↑ ACh
Nozaki et al. [20] (2007) Male Lewis rat AIA M. butyricum (tail) Keishibukuryogan 1–1.2 g/kg per day (po) from day 0 to day 25 post-injection ↑ ACh =
Haruna et al. [18] (2006) Male Lewis rat AIA M. butyricum (tail) BH4 20 mg/kg (ip) from day 21 to day 35 post-injection ↑ ACh = SNP =
Haruna et al. [19] (2007) Male Lewis rat AIA M. butyricum (tail) Fluvastatin 5 mg/kg per day (po) from day 21 to day 35 post-injection ↑ ACh =
Sakuta et al. [21] (2010) Male Lewis rat AIA M. butyricum (tail) Losartan 3 mg/kg per day (po) and Irbesartan 5 mg/kg per day (po) from day 14 to day 35 post-injection ↑ ACh = SNP =
Prati et al. [23] (2012) Male Lewis rat AIA M. butyricum (tail) Nor-NOHA 40 mg/kg per day (ip) from day 14 to day 35 post-injection ↑ ACh = SNP = NE, ANG-II, ET-1 =
He et al. [25] (2013) Male DBA/1 mice CIA Bovine collagen (tail) Simvastatin 50 mg/kg per day (po) from day 7 before injection to day 56 post-injection ↑ ACh = SNP =
  1. Vascular reactivity was studied in the model of isolated aortic rings. ↑, increased; ↓, decreased; =, unchanged; ACh, acetylcholine; AIA, adjuvant-induced arthritis; ANG-II, angiotensin II; BH4, tetrahydrobiopterin; CIA, collagen-induced arthritis; ET-1, endothelin-1; im, intramuscular; ip, intraperitoneal; KCl, high potassium chloride; NE, norepinephrine; nor-NOHA, Nw-hydroxy-nor-L-arginine; NR, not reported; PE, phenylephrine; po, per os; SNP, sodium nitroprusside.