From: Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies
Authors (year) | Animal strain | Arthritis model Arthritogenetic agent( injection zone) | Treatment | Vascular reactivity | Arthritis severity |
---|---|---|---|---|---|
Cinar et al. [15] (1998) | Male rat (strain NR) | AIA M. tuberculosis (pad) | Vitamin E 100 mg/kg per day (im) from day 0 to day 26 post-injection | ↓ ACh, ↑ PE | ↓ |
Ulker et al. [16] (2000) | Male Wistar rat | AIA M. tuberculosis (pad) | Nabumetone 120 and 240 mg/kg per day (po) from day 14 to day 28 post-injection | Normalization of responses to Ach and SNP | = (120 mg/kg per day) ↓ (240 mg/kg per day) |
Can et al. [17] (2002) | Male Wistar rat | AIA M. tuberculosis (pad) | Vitamin E 100 mg/kg per day (im) from day 0 to day 26 post-injection | ↑ ACh | ↓ |
Nozaki et al. [20] (2007) | Male Lewis rat | AIA M. butyricum (tail) | Keishibukuryogan 1–1.2 g/kg per day (po) from day 0 to day 25 post-injection | ↑ ACh | = |
Haruna et al. [18] (2006) | Male Lewis rat | AIA M. butyricum (tail) | BH4 20 mg/kg (ip) from day 21 to day 35 post-injection | ↑ ACh = SNP | = |
Haruna et al. [19] (2007) | Male Lewis rat | AIA M. butyricum (tail) | Fluvastatin 5 mg/kg per day (po) from day 21 to day 35 post-injection | ↑ ACh | = |
Sakuta et al. [21] (2010) | Male Lewis rat | AIA M. butyricum (tail) | Losartan 3 mg/kg per day (po) and Irbesartan 5 mg/kg per day (po) from day 14 to day 35 post-injection | ↑ ACh = SNP | = |
Prati et al. [23] (2012) | Male Lewis rat | AIA M. butyricum (tail) | Nor-NOHA 40 mg/kg per day (ip) from day 14 to day 35 post-injection | ↑ ACh = SNP = NE, ANG-II, ET-1 | = |
He et al. [25] (2013) | Male DBA/1 mice | CIA Bovine collagen (tail) | Simvastatin 50 mg/kg per day (po) from day 7 before injection to day 56 post-injection | ↑ ACh = SNP | = |