The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case–control study

Table 2 Association between all single-nucleotide polymorphisms and chondrocalcinosis in the Genetics of Osteoarthritis and Lifestyle study

	SNP	Reason for selection (association with):	Minor allele frequency, %		OR_GENOTYPE(95% CI)	P
	SNP	Reason for selection (association with):	CC +	CC -	OR_GENOTYPE(95% CI)	P
ANKH	-4bpG > A 5′ UTR	Chondrocalcinosis [14]	11.0	8.2	1.36 (1.07-1.73)	0.013
	rs3045	Rotator cuff tear and low intracellular PPi [18]	12.7	10.1	1.28 (1.02-1.60)	0.030
	rs39968	Parathyroid hormone level [19]	28.1	30.9	0.89 (0.76-1.05)	0.160
	rs875525	Parathyroid hormone level [19]	28.1	25.6	0.89 (0.76-1.04)	0.152
HFE	rs1800562	Hemochromatosis [20, 21]	7.8	7.8	1.01 (0.77-1.33)	0.937
	rs1799945	Hemochromatosis [20, 21]	17.1	14.7	1.20 (0.99-1.46)	0.070
TNAP	rs3200254	Increased TNAP activity [22]	11.1	11.0	0.99 (0.79-1.25)	0.957
	rs4654760	Rotator cuff tear [18]	6.7	6.6	1.01 (0.76-1.35)	0.955
ENPP1	rs1044498	Osteoarthritis [23]	13.7	12.5	1.07 (0.86-1.32)	0.564
	rs28933977	Osteoarthritis [23]	3.7	4.1	0.81 (0.55-1.20)	0.826
	rs1800949	Osteoarthritis [23]	25.7	26.2	0.98 (0.83-1.16)	0.298
	rs858342	Osteoarthritis [23]	24.1	25.1	0.92 (0.78-1.10)	0.365
	rs943003	Obesity [24]	40.6	41.9	1.06 (0.86-1.32)	0.401
Transferrin	rs1799852	Iron overload [25]	8.2	9.4	0.89 (0.69-1.15)	0.372
	rs2280673	Iron overload [25]	34.7	35.4	0.97 (0.83-1.12)	0.664
	rs3811647	Iron overload [25]	36.5	34.7	1.08 (0.92-1.26)	0.348

5′ UTR, 5′ untranslated region; ANKH, ankylosis human; CC, chondrocalcinosis; CI, confidence interval; ENPP1, ecto-neucleotide pyrophosphatase 1; HFE, high ferritin; OR_GENOTYPE, genotype odds ratio; PPi, pyrophosphate; SNP, single-nucleotide polymorphism; TNAP, tissue non-specific alkaline phosphatase.

ISSN: 1478-6362