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Table 2 Association between all single-nucleotide polymorphisms and chondrocalcinosis in the Genetics of Osteoarthritis and Lifestyle study

From: The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case–control study

  SNP Reason for selection (association with): Minor allele frequency, % ORGENOTYPE(95% CI) P
CC + CC -
ANKH -4bpG > A 5′ UTR Chondrocalcinosis [14] 11.0 8.2 1.36 (1.07-1.73) 0.013
  rs3045 Rotator cuff tear and low intracellular PPi [18] 12.7 10.1 1.28 (1.02-1.60) 0.030
  rs39968 Parathyroid hormone level [19] 28.1 30.9 0.89 (0.76-1.05) 0.160
  rs875525 Parathyroid hormone level [19] 28.1 25.6 0.89 (0.76-1.04) 0.152
HFE rs1800562 Hemochromatosis [20, 21] 7.8 7.8 1.01 (0.77-1.33) 0.937
  rs1799945 Hemochromatosis [20, 21] 17.1 14.7 1.20 (0.99-1.46) 0.070
TNAP rs3200254 Increased TNAP activity [22] 11.1 11.0 0.99 (0.79-1.25) 0.957
  rs4654760 Rotator cuff tear [18] 6.7 6.6 1.01 (0.76-1.35) 0.955
ENPP1 rs1044498 Osteoarthritis [23] 13.7 12.5 1.07 (0.86-1.32) 0.564
  rs28933977 Osteoarthritis [23] 3.7 4.1 0.81 (0.55-1.20) 0.826
  rs1800949 Osteoarthritis [23] 25.7 26.2 0.98 (0.83-1.16) 0.298
  rs858342 Osteoarthritis [23] 24.1 25.1 0.92 (0.78-1.10) 0.365
  rs943003 Obesity [24] 40.6 41.9 1.06 (0.86-1.32) 0.401
Transferrin rs1799852 Iron overload [25] 8.2 9.4 0.89 (0.69-1.15) 0.372
  rs2280673 Iron overload [25] 34.7 35.4 0.97 (0.83-1.12) 0.664
  rs3811647 Iron overload [25] 36.5 34.7 1.08 (0.92-1.26) 0.348
  1. 5′ UTR, 5′ untranslated region; ANKH, ankylosis human; CC, chondrocalcinosis; CI, confidence interval; ENPP1, ecto-neucleotide pyrophosphatase 1; HFE, high ferritin; ORGENOTYPE, genotype odds ratio; PPi, pyrophosphate; SNP, single-nucleotide polymorphism; TNAP, tissue non-specific alkaline phosphatase.