TY - JOUR AU - Kill, Angela AU - Tabeling, Christoph AU - Undeutsch, Reinmar AU - Kühl, Anja A. AU - Günther, Jeannine AU - Radic, Mislav AU - Becker, Mike O. AU - Heidecke, Harald AU - Worm, Margitta AU - Witzenrath, Martin AU - Burmester, Gerd-Rüdiger AU - Dragun, Duska AU - Riemekasten, Gabriela PY - 2014 DA - 2014/01/28 TI - Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis JO - Arthritis Research & Therapy SP - R29 VL - 16 IS - 1 AB - Vasculopathy, inflammatory fibrosis and functional autoantibodies (Abs) are major manifestations of systemic sclerosis (SSc). Abs directed against the angiotensin II type 1 receptor (AT1R) and endothelin-1 type A receptor (ETAR) are associated with characteristic disease features including vascular, inflammatory, and fibrotic complications indicating their role in SSc pathogenesis. Therefore, the impact of anti-AT1R and anti-ETAR Abs on initiation of inflammation and fibrosis was analyzed. SN - 1478-6362 UR - https://doi.org/10.1186/ar4457 DO - 10.1186/ar4457 ID - Kill2014 ER -