TY - JOUR AU - Strine, T. W. AU - Hootman, J. M. PY - 2007 DA - 2007// TI - US national prevalence and correlates of low back and neck pain among adults JO - Arthritis Rheum VL - 57 UR - https://doi.org/10.1002/art.22684 DO - 10.1002/art.22684 ID - Strine2007 ER - TY - JOUR AU - Luo, X. AU - Pietrobon, R. AU - Sun, S. X. AU - Liu, G. G. AU - Hey, L. PY - 2004 DA - 2004// TI - Estimates and patterns of direct health care expenditures among individuals with back pain in the United States JO - Spine (Phila Pa 1976) VL - 29 UR - https://doi.org/10.1097/01.BRS.0000105527.13866.0F DO - 10.1097/01.BRS.0000105527.13866.0F ID - Luo2004 ER - TY - JOUR AU - Stewart, W. F. AU - Ricci, J. A. AU - Chee, E. AU - Morganstein, D. AU - Lipton, R. PY - 2003 DA - 2003// TI - Lost productive time and cost due to common pain conditions in the US workforce JO - JAMA VL - 290 UR - https://doi.org/10.1001/jama.290.18.2443 DO - 10.1001/jama.290.18.2443 ID - Stewart2003 ER - TY - JOUR AU - Livshits, G. AU - Popham, M. AU - Malkin, I. AU - Sambrook, P. N. AU - Macgregor, A. J. AU - Spector, T. AU - Williams, F. M. PY - 2011 DA - 2011// TI - Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study JO - Ann Rheum Dis VL - 70 UR - https://doi.org/10.1136/ard.2010.137836 DO - 10.1136/ard.2010.137836 ID - Livshits2011 ER - TY - JOUR AU - Hunter, C. J. AU - Matyas, J. R. AU - Duncan, N. A. PY - 2003 DA - 2003// TI - The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering JO - Tissue Eng VL - 9 UR - https://doi.org/10.1089/107632703768247368 DO - 10.1089/107632703768247368 ID - Hunter2003 ER - TY - JOUR AU - Alini, M. AU - Eisenstein, S. M. AU - Ito, K. AU - Little, C. AU - Kettler, A. A. AU - Masuda, K. AU - Melrose, J. AU - Ralphs, J. AU - Stokes, I. AU - Wilke, H. J. PY - 2008 DA - 2008// TI - Are animal models useful for studying human disc disorders/degeneration? JO - Eur Spine J VL - 17 UR - https://doi.org/10.1007/s00586-007-0414-y DO - 10.1007/s00586-007-0414-y ID - Alini2008 ER - TY - JOUR AU - Choi, K. S. AU - Cohn, M. J. AU - Harfe, B. D. PY - 2008 DA - 2008// TI - Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation JO - Dev Dyn VL - 237 UR - https://doi.org/10.1002/dvdy.21805 DO - 10.1002/dvdy.21805 ID - Choi2008 ER - TY - JOUR AU - Urban, J. P. AU - Roberts, S. PY - 2003 DA - 2003// TI - Degeneration of the intervertebral disc JO - Arthritis Res Ther VL - 5 UR - https://doi.org/10.1186/ar629 DO - 10.1186/ar629 ID - Urban2003 ER - TY - JOUR AU - Antoniou, J. AU - Steffen, T. AU - Nelson, F. AU - Winterbottom, N. AU - Hollander, A. P. AU - Poole, R. A. AU - Aebi, M. AU - Alini, M. PY - 1996 DA - 1996// TI - The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration JO - J Clin Invest VL - 98 UR - https://doi.org/10.1172/JCI118884 DO - 10.1172/JCI118884 ID - Antoniou1996 ER - TY - JOUR AU - Boos, N. AU - Weissbach, S. AU - Rohrbach, H. AU - Weiler, C. AU - Spratt, K. F. AU - Nerlich, A. G. PY - 2002 DA - 2002// TI - Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science JO - Spine (Phila Pa 1976) VL - 27 UR - https://doi.org/10.1097/00007632-200212010-00002 DO - 10.1097/00007632-200212010-00002 ID - Boos2002 ER - TY - JOUR AU - Fuchs, Y. AU - Steller, H. PY - 2011 DA - 2011// TI - Programmed cell death in animal development and disease JO - Cell VL - 147 UR - https://doi.org/10.1016/j.cell.2011.10.033 DO - 10.1016/j.cell.2011.10.033 ID - Fuchs2011 ER - TY - JOUR AU - Jin, Z. AU - El-Deiry, W. S. PY - 2005 DA - 2005// TI - Overview of cell death signaling pathways JO - Cancer Biol Ther VL - 4 UR - https://doi.org/10.4161/cbt.4.2.1508 DO - 10.4161/cbt.4.2.1508 ID - Jin2005 ER - TY - JOUR AU - Luo, J. AU - Nikolaev, A. Y. AU - Imai, S. AU - Chen, D. AU - Su, F. AU - Shiloh, A. AU - Guarente, L. AU - Gu, W. PY - 2001 DA - 2001// TI - Negative control of p53 by Sir2alpha promotes cell survival under stress JO - Cell VL - 107 UR - https://doi.org/10.1016/S0092-8674(01)00524-4 DO - 10.1016/S0092-8674(01)00524-4 ID - Luo2001 ER - TY - JOUR AU - Vaziri, H. AU - Dessain, S. K. AU - Ng Eaton, E. AU - Imai, S. I. AU - Frye, R. A. AU - Pandita, T. K. AU - Guarente, L. AU - Weinberg, R. A. PY - 2001 DA - 2001// TI - hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase JO - Cell VL - 107 UR - https://doi.org/10.1016/S0092-8674(01)00527-X DO - 10.1016/S0092-8674(01)00527-X ID - Vaziri2001 ER - TY - JOUR AU - Toledo, F. AU - Krummel, K. A. AU - Lee, C. J. AU - Liu, C. W. AU - Rodewald, L. W. AU - Tang, M. AU - Wahl, G. M. PY - 2006 DA - 2006// TI - A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network JO - Cancer Cell VL - 9 UR - https://doi.org/10.1016/j.ccr.2006.03.014 DO - 10.1016/j.ccr.2006.03.014 ID - Toledo2006 ER - TY - JOUR AU - Oda, K. AU - Arakawa, H. AU - Tanaka, T. AU - Matsuda, K. AU - Tanikawa, C. AU - Mori, T. AU - Nishimori, H. AU - Tamai, K. AU - Tokino, T. AU - Nakamura, Y. AU - Taya, Y. PY - 2000 DA - 2000// TI - p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 JO - Cell VL - 102 UR - https://doi.org/10.1016/S0092-8674(00)00073-8 DO - 10.1016/S0092-8674(00)00073-8 ID - Oda2000 ER - TY - JOUR AU - Matsuda, K. AU - Yoshida, K. AU - Taya, Y. AU - Nakamura, K. AU - Nakamura, Y. AU - Arakawa, H. PY - 2002 DA - 2002// TI - p53AIP1 regulates the mitochondrial apoptotic pathway JO - Cancer Res VL - 62 ID - Matsuda2002 ER - TY - JOUR AU - Gruber, H. E. AU - Hanley, E. N. PY - 1998 DA - 1998// TI - Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls JO - Spine (Phila Pa 1976) VL - 23 UR - https://doi.org/10.1097/00007632-199804010-00001 DO - 10.1097/00007632-199804010-00001 ID - Gruber1998 ER - TY - JOUR AU - Yurube, T. AU - Nishida, K. AU - Suzuki, T. AU - Kaneyama, S. AU - Zhang, Z. AU - Kakutani, K. AU - Maeno, K. AU - Takada, T. AU - Fujii, M. AU - Kurosaka, M. AU - Doita, M. PY - 2010 DA - 2010// TI - Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model JO - J Orthop Res VL - 28 ID - Yurube2010 ER - TY - JOUR AU - Yurube, T. AU - Takada, T. AU - Suzuki, T. AU - Kakutani, K. AU - Maeno, K. AU - Doita, M. AU - Kurosaka, M. AU - Nishida, K. PY - 2012 DA - 2012// TI - Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration JO - Arthritis Res Ther VL - 14 UR - https://doi.org/10.1186/ar3764 DO - 10.1186/ar3764 ID - Yurube2012 ER - TY - JOUR AU - Sztrolovics, R. AU - Alini, M. AU - Roughley, P. J. AU - Mort, J. S. PY - 1997 DA - 1997// TI - Aggrecan degradation in human intervertebral disc and articular cartilage JO - Biochem J VL - 326 UR - https://doi.org/10.1042/bj3260235 DO - 10.1042/bj3260235 ID - Sztrolovics1997 ER - TY - JOUR AU - Roberts, S. AU - Caterson, B. AU - Menage, J. AU - Evans, E. H. AU - Jaffray, D. C. AU - Eisenstein, S. M. PY - 2000 DA - 2000// TI - Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc JO - Spine (Phila Pa 1976) VL - 25 UR - https://doi.org/10.1097/00007632-200012010-00007 DO - 10.1097/00007632-200012010-00007 ID - Roberts2000 ER - TY - JOUR AU - Lotz, J. C. AU - Colliou, O. K. AU - Chin, J. R. AU - Duncan, N. A. AU - Liebenberg, E. PY - 1998 DA - 1998// TI - Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study JO - Spine (Phila Pa 1976) VL - 23 UR - https://doi.org/10.1097/00007632-199812010-00004 DO - 10.1097/00007632-199812010-00004 ID - Lotz1998 ER - TY - JOUR AU - Lotz, J. C. AU - Chin, J. R. PY - 2000 DA - 2000// TI - Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading JO - Spine (Phila Pa 1976) VL - 25 ID - Lotz2000 ER - TY - JOUR AU - Hutton, W. C. AU - Ganey, T. M. AU - Elmer, W. A. AU - Kozlowska, E. AU - Ugbo, J. L. AU - Doh, E. S. AU - Whitesides, T. E. PY - 2000 DA - 2000// TI - Does long-term compressive loading on the intervertebral disc cause degeneration? JO - Spine (Phila Pa 1976) VL - 25 UR - https://doi.org/10.1097/00007632-200012010-00006 DO - 10.1097/00007632-200012010-00006 ID - Hutton2000 ER - TY - JOUR AU - Kroeber, M. W. AU - Unglaub, F. AU - Wang, H. AU - Schmid, C. AU - Thomsen, M. AU - Nerlich, A. AU - Richter, W. PY - 2002 DA - 2002// TI - New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration JO - Spine (Phila Pa 1976) VL - 27 UR - https://doi.org/10.1097/00007632-200212010-00007 DO - 10.1097/00007632-200212010-00007 ID - Kroeber2002 ER - TY - JOUR AU - Rannou, F. AU - Lee, T. S. AU - Zhou, R. H. AU - Chin, J. AU - Lotz, J. C. AU - Mayoux-Benhamou, M. A. AU - Barbet, J. P. AU - Chevrot, A. AU - Shyy, J. Y. PY - 2004 DA - 2004// TI - Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload JO - Am J Pathol VL - 164 UR - https://doi.org/10.1016/S0002-9440(10)63179-3 DO - 10.1016/S0002-9440(10)63179-3 ID - Rannou2004 ER - TY - JOUR AU - Hughes, P. C. AU - Tanner, J. M. PY - 1970 DA - 1970// TI - The assessment of skeletal maturity in the growing rat JO - J Anat VL - 106 ID - Hughes1970 ER - TY - JOUR AU - Iatridis, J. C. AU - Mente, P. L. AU - Stokes, I. A. AU - Aronsson, D. D. AU - Alini, M. PY - 1999 DA - 1999// TI - Compression-induced changes in intervertebral disc properties in a rat tail model JO - Spine (Phila Pa 1976) VL - 24 UR - https://doi.org/10.1097/00007632-199905150-00013 DO - 10.1097/00007632-199905150-00013 ID - Iatridis1999 ER - TY - JOUR AU - Yurube, T. AU - Takada, T. AU - Hirata, H. AU - Kakutani, K. AU - Maeno, K. AU - Zhang, Z. AU - Yamamoto, J. AU - Doita, M. AU - Kurosaka, M. AU - Nishida, K. PY - 2011 DA - 2011// TI - Modified house-keeping gene expression in a rat tail compression loading-induced disc degeneration model JO - J Orthop Res VL - 29 UR - https://doi.org/10.1002/jor.21406 DO - 10.1002/jor.21406 ID - Yurube2011 ER - TY - JOUR AU - Guehring, T. AU - Nerlich, A. AU - Kroeber, M. AU - Richter, W. AU - Omlor, G. W. PY - 2010 DA - 2010// TI - Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study JO - Eur Spine J VL - 19 UR - https://doi.org/10.1007/s00586-009-1217-0 DO - 10.1007/s00586-009-1217-0 ID - Guehring2010 ER - TY - JOUR AU - Arun, R. AU - Freeman, B. J. AU - Scammell, B. E. AU - McNally, D. S. AU - Cox, E. AU - Gowland, P. PY - 2009 DA - 2009// TI - ISSLS Prize Winner: What influence does sustained mechanical load have on diffusion in the human intervertebral disc?: an in vivo study using serial postcontrast magnetic resonance imaging JO - Spine (Phila Pa 1976) VL - 34 UR - https://doi.org/10.1097/BRS.0b013e3181b4df92 DO - 10.1097/BRS.0b013e3181b4df92 ID - Arun2009 ER - TY - JOUR AU - Guehring, T. AU - Wilde, G. AU - Sumner, M. AU - Grunhagen, T. AU - Karney, G. B. AU - Tirlapur, U. K. AU - Urban, J. P. PY - 2009 DA - 2009// TI - Notochordal intervertebral disc cells: sensitivity to nutrient deprivation JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24407 DO - 10.1002/art.24407 ID - Guehring2009 ER - TY - JOUR AU - Trout, J. J. AU - Buckwalter, J. A. AU - Moore, K. C. PY - 1982 DA - 1982// TI - Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus JO - Anat Rec VL - 204 UR - https://doi.org/10.1002/ar.1092040403 DO - 10.1002/ar.1092040403 ID - Trout1982 ER - TY - JOUR AU - Hashimoto, S. AU - Nishiyama, T. AU - Hayashi, S. AU - Fujishiro, T. AU - Takebe, K. AU - Kanzaki, N. AU - Kuroda, R. AU - Kurosaka, M. PY - 2009 DA - 2009// TI - Role of p53 in human chondrocyte apoptosis in response to shear strain JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24706 DO - 10.1002/art.24706 ID - Hashimoto2009 ER - TY - JOUR AU - Kim, H. A. AU - Lee, Y. J. AU - Seong, S. C. AU - Choe, K. W. AU - Song, Y. W. PY - 2000 DA - 2000// TI - Apoptotic chondrocyte death in human osteoarthritis JO - J Rheumatol VL - 27 ID - Kim2000 ER - TY - JOUR AU - Takayama, K. AU - Ishida, K. AU - Matsushita, T. AU - Fujita, N. AU - Hayashi, S. AU - Sasaki, K. AU - Tei, K. AU - Kubo, S. AU - Matsumoto, T. AU - Fujioka, H. AU - Kurosaka, M. AU - Kuroda, R. PY - 2009 DA - 2009// TI - SIRT1 regulation of apoptosis of human chondrocytes JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24864 DO - 10.1002/art.24864 ID - Takayama2009 ER - TY - JOUR AU - Sudo, H. AU - Minami, A. PY - 2010 DA - 2010// TI - Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression JO - J Orthop Res VL - 28 UR - https://doi.org/10.1002/jor.21185 DO - 10.1002/jor.21185 ID - Sudo2010 ER - TY - JOUR AU - Matsushita, T. AU - Sasaki, H. AU - Takayama, K. AU - Ishida, K. AU - Matsumoto, T. AU - Kubo, S. AU - Matsuzaki, T. AU - Nishida, K. AU - Kurosaka, M. AU - Kuroda, R. PY - 2013 DA - 2013// TI - The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1beta in human chondrocytes JO - J Orthop Res VL - 31 UR - https://doi.org/10.1002/jor.22268 DO - 10.1002/jor.22268 ID - Matsushita2013 ER - TY - JOUR AU - Yang, F. AU - Leung, V. Y. AU - Luk, K. D. AU - Chan, D. AU - Cheung, K. M. PY - 2009 DA - 2009// TI - Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse JO - J Pathol VL - 218 UR - https://doi.org/10.1002/path.2519 DO - 10.1002/path.2519 ID - Yang2009 ER - TY - JOUR AU - Duan, W. R. AU - Garner, D. S. AU - Williams, S. D. AU - Funckes-Shippy, C. L. AU - Spath, I. S. AU - Blomme, E. A. PY - 2003 DA - 2003// TI - Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts JO - J Pathol VL - 199 UR - https://doi.org/10.1002/path.1289 DO - 10.1002/path.1289 ID - Duan2003 ER - TY - JOUR AU - Sowa, G. AU - Vadala, G. AU - Studer, R. AU - Kompel, J. AU - Iucu, C. AU - Georgescu, H. AU - Gilbertson, L. AU - Kang, J. PY - 2008 DA - 2008// TI - Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression JO - Spine (Phila Pa 1976) VL - 33 UR - https://doi.org/10.1097/BRS.0b013e31817e2ce3 DO - 10.1097/BRS.0b013e31817e2ce3 ID - Sowa2008 ER - TY - JOUR AU - Erwin, W. M. AU - Islam, D. AU - Inman, R. D. AU - Fehlings, M. G. AU - Tsui, F. W. PY - 2011 DA - 2011// TI - Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration JO - Arthritis Res Ther VL - 13 UR - https://doi.org/10.1186/ar3548 DO - 10.1186/ar3548 ID - Erwin2011 ER - TY - JOUR AU - Cappello, R. AU - Bird, J. L. AU - Pfeiffer, D. AU - Bayliss, M. T. AU - Dudhia, J. PY - 2006 DA - 2006// TI - Notochordal cell produce and assemble extracellular matrix in a distinct manner, which may be responsible for the maintenance of healthy nucleus pulposus JO - Spine (Phila Pa 1976) VL - 31 UR - https://doi.org/10.1097/01.brs.0000209302.00820.fd DO - 10.1097/01.brs.0000209302.00820.fd ID - Cappello2006 ER - TY - JOUR AU - Erwin, W. M. AU - Inman, R. D. PY - 2006 DA - 2006// TI - Notochord cells regulate intervertebral disc chondrocyte proteoglycan production and cell proliferation JO - Spine (Phila Pa 1976) VL - 31 UR - https://doi.org/10.1097/01.brs.0000216593.97157.dd DO - 10.1097/01.brs.0000216593.97157.dd ID - Erwin2006 ER - TY - JOUR AU - Oguz, E. AU - Tsai, T. T. AU - Di Martino, A. AU - Guttapalli, A. AU - Albert, T. J. AU - Shapiro, I. M. AU - Risbud, M. V. PY - 2007 DA - 2007// TI - Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype? JO - Spine (Phila Pa 1976) VL - 32 UR - https://doi.org/10.1097/01.brs.0000250302.74574.98 DO - 10.1097/01.brs.0000250302.74574.98 ID - Oguz2007 ER - TY - JOUR AU - Minogue, B. M. AU - Richardson, S. M. AU - Zeef, L. A. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2010 DA - 2010// TI - Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes JO - Arthritis Res Ther VL - 12 UR - https://doi.org/10.1186/ar2929 DO - 10.1186/ar2929 ID - Minogue2010 ER - TY - JOUR AU - Gilson, A. AU - Dreger, M. AU - Urban, J. P. PY - 2010 DA - 2010// TI - Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers JO - Arthritis Res Ther VL - 12 UR - https://doi.org/10.1186/ar2931 DO - 10.1186/ar2931 ID - Gilson2010 ER - TY - JOUR AU - Weiler, C. AU - Nerlich, A. G. AU - Schaaf, R. AU - Bachmeier, B. E. AU - Wuertz, K. AU - Boos, N. PY - 2010 DA - 2010// TI - Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc JO - Eur Spine J VL - 19 UR - https://doi.org/10.1007/s00586-010-1392-z DO - 10.1007/s00586-010-1392-z ID - Weiler2010 ER - TY - JOUR AU - Risbud, M. V. AU - Shapiro, I. M. PY - 2011 DA - 2011// TI - Notochordal cells in the adult intervertebral disc: new perspective on an old question JO - Crit Rev Eukaryot Gene Expr VL - 21 UR - https://doi.org/10.1615/CritRevEukarGeneExpr.v21.i1.30 DO - 10.1615/CritRevEukarGeneExpr.v21.i1.30 ID - Risbud2011 ER - TY - JOUR AU - Sudo, H. AU - Minami, A. PY - 2011 DA - 2011// TI - Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits JO - Arthritis Rheum VL - 63 UR - https://doi.org/10.1002/art.30251 DO - 10.1002/art.30251 ID - Sudo2011 ER - TY - JOUR AU - Rebbaa, A. AU - Zheng, X. AU - Chou, P. M. AU - Mirkin, B. L. PY - 2003 DA - 2003// TI - Caspase inhibition switches doxorubicin-induced apoptosis to senescence JO - Oncogene VL - 22 UR - https://doi.org/10.1038/sj.onc.1206366 DO - 10.1038/sj.onc.1206366 ID - Rebbaa2003 ER - TY - JOUR AU - Vandenabeele, P. AU - Vanden Berghe, T. AU - Festjens, N. PY - 2006 DA - 2006// TI - Caspase inhibitors promote alternative cell death pathways JO - Sci STKE VL - 2006 UR - https://doi.org/10.1126/stke.3582006pe44 DO - 10.1126/stke.3582006pe44 ID - Vandenabeele2006 ER -