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Table 1 Baseline characteristics of patients by study and symptom duration group

From: Good correlation between changes in objective and subjective signs of inflammation in patients with short- but not long duration of axial spondyloarthritis treated with tumor necrosis factor-blockers

  Pooled data Etanercept Adalimumab
  <4 years ≥4 years P-value <4 years ≥4 years P-value <4 years ≥4 years P-value
  n = 58 n = 54   n = 42 n = 24   n = 16 n = 30  
Symptom duration mean (SD) 2 (1.1) 7.7 (5)   2 (1.1) 5.2 (0.9)   1.9 (1) 9.7 (5.9)  
Age, years, mean (SD) 31.7 (8.1) 37.8 (8.4) 0.001 31.6 (8.2) 37 (7.7) 0.01 31.8 (8.1) 38.5 (9.1) 0.02
Male, n (%) 30 (51.7) 28 (51.9) 0.99 25 (59.5) 12 (50) 0.45 5 (31.3) 16 (53.3) 0.15
HLA-B27-positive, n (%) 45 (77.6) 41 (75.9) 0.84 33 (78.6) 22 (91.7) 0.17 12 (75) 19 (63.3) 0.42
Joints with arthritis, mean (SD) 1.1 (3.3) 1.7 (6.4) 0.30 1.4 (3.9) 1.9 (6) 0.33 0.4 (0.7) 1.6 (6.7) 0.86
Joints with enthesitis, mean (SD) 2.5 (3.6) 3.5 (3.8) 0.095 2.7 (4) 3.7 (4.6) 0.41 2 (2.7) 3.3 (3.1) 0.16
BASDAI, mean (SD) 4.9 (1.9) 6 (1.8) 0.004 5 (1.7) 5.5 (2) 0.29 4.7 (2.4) 6.3 (1.5) 0.009
BASFI, mean (SD) 3.8 (2.4) 5 (2.1) 0.007 3.9 (2.2) 4.4 (2.3) 0.34 3.6 (2.8) 5.4 (1.9) 0.01
BASMI mean (SD) 1.5 (1.3) 2.1 (1.8) 0.057 1.7 (1.4) 2.6 (2) 0.04 1.1 (0.9) 1.7 (1.6) 0.16
ASDAS, mean (SD) 3.1 (0.9) 3.1 (0.8) 0.95 3.2 (0.8) 3 (1) 0.49 2.9 (0.9) 3.2 (0.6) 0.22
CRP, mg/l, mean (SD) 9 (9.3) 6.9 (9.6) 0.018 9.7 (10.4) 8.8 (13.4) 0.18 7.4 (6) 5.4 (5.2) 0.14
log CRP, mg/l, mean (SD) 2 (0.7) 1.7 (0.8) 0.018 2.1 (0.8) 1.8 (0.8) 0.26 1.9 (0.7) 1.5 (0.8) 0.16
CRP-negative, n (%) 26 (46.4) 37 (71.2) 0.009 18 (42.9) 16 (66.7) 0.04 8 (50) 21 (70) 0.18
MRI SIJ score, mean (SD) 6.2 (6.1) 4.1 (4.7) 0.08 6.4 (6) 5 (5.7) 0.21 5.4 (7) 3.2 (3.4) 0.61
  1. P-value <0.05 was taken to indicate statistically significant differences between two groups. HLA-B27, human leukocyte antigen-B27; BASDAI, Bath ankylosing spondylitis disease activity index; BASFI, Bath ankylosing spondylitis functional index; BASMI, Bath ankylosing spondylitis metrology index; ASDAS, ankylosing spondylitis disease activity score; CRP, C-reactive protein; MRI, magnetic resonance imaging; SIJ, sacroiliac joint.