| |
Pooled data
|
Etanercept
|
Adalimumab
|
|---|
| |
<4 years
|
≥4 years
|
P-value
|
<4 years
|
≥4 years
|
P-value
|
<4 years
|
≥4 years
|
P-value
|
|---|
| |
n = 58
|
n = 54
| |
n = 42
|
n = 24
| |
n = 16
|
n = 30
| |
|---|
|
Symptom duration mean (SD)
|
2 (1.1)
|
7.7 (5)
| |
2 (1.1)
|
5.2 (0.9)
| |
1.9 (1)
|
9.7 (5.9)
| |
|
Age, years, mean (SD)
|
31.7 (8.1)
|
37.8 (8.4)
|
0.001
|
31.6 (8.2)
|
37 (7.7)
|
0.01
|
31.8 (8.1)
|
38.5 (9.1)
|
0.02
|
|
Male, n (%)
|
30 (51.7)
|
28 (51.9)
|
0.99
|
25 (59.5)
|
12 (50)
|
0.45
|
5 (31.3)
|
16 (53.3)
|
0.15
|
|
HLA-B27-positive, n (%)
|
45 (77.6)
|
41 (75.9)
|
0.84
|
33 (78.6)
|
22 (91.7)
|
0.17
|
12 (75)
|
19 (63.3)
|
0.42
|
|
Joints with arthritis, mean (SD)
|
1.1 (3.3)
|
1.7 (6.4)
|
0.30
|
1.4 (3.9)
|
1.9 (6)
|
0.33
|
0.4 (0.7)
|
1.6 (6.7)
|
0.86
|
|
Joints with enthesitis, mean (SD)
|
2.5 (3.6)
|
3.5 (3.8)
|
0.095
|
2.7 (4)
|
3.7 (4.6)
|
0.41
|
2 (2.7)
|
3.3 (3.1)
|
0.16
|
|
BASDAI, mean (SD)
|
4.9 (1.9)
|
6 (1.8)
|
0.004
|
5 (1.7)
|
5.5 (2)
|
0.29
|
4.7 (2.4)
|
6.3 (1.5)
|
0.009
|
|
BASFI, mean (SD)
|
3.8 (2.4)
|
5 (2.1)
|
0.007
|
3.9 (2.2)
|
4.4 (2.3)
|
0.34
|
3.6 (2.8)
|
5.4 (1.9)
|
0.01
|
|
BASMI mean (SD)
|
1.5 (1.3)
|
2.1 (1.8)
|
0.057
|
1.7 (1.4)
|
2.6 (2)
|
0.04
|
1.1 (0.9)
|
1.7 (1.6)
|
0.16
|
|
ASDAS, mean (SD)
|
3.1 (0.9)
|
3.1 (0.8)
|
0.95
|
3.2 (0.8)
|
3 (1)
|
0.49
|
2.9 (0.9)
|
3.2 (0.6)
|
0.22
|
|
CRP, mg/l, mean (SD)
|
9 (9.3)
|
6.9 (9.6)
|
0.018
|
9.7 (10.4)
|
8.8 (13.4)
|
0.18
|
7.4 (6)
|
5.4 (5.2)
|
0.14
|
|
log CRP, mg/l, mean (SD)
|
2 (0.7)
|
1.7 (0.8)
|
0.018
|
2.1 (0.8)
|
1.8 (0.8)
|
0.26
|
1.9 (0.7)
|
1.5 (0.8)
|
0.16
|
|
CRP-negative, n (%)
|
26 (46.4)
|
37 (71.2)
|
0.009
|
18 (42.9)
|
16 (66.7)
|
0.04
|
8 (50)
|
21 (70)
|
0.18
|
|
MRI SIJ score, mean (SD)
|
6.2 (6.1)
|
4.1 (4.7)
|
0.08
|
6.4 (6)
|
5 (5.7)
|
0.21
|
5.4 (7)
|
3.2 (3.4)
|
0.61
|
- P-value <0.05 was taken to indicate statistically significant differences between two groups. HLA-B27, human leukocyte antigen-B27; BASDAI, Bath ankylosing spondylitis disease activity index; BASFI, Bath ankylosing spondylitis functional index; BASMI, Bath ankylosing spondylitis metrology index; ASDAS, ankylosing spondylitis disease activity score; CRP, C-reactive protein; MRI, magnetic resonance imaging; SIJ, sacroiliac joint.
