Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year

Table 1 Baseline characteristics by APR levels

	Neither APR elevated	APR levels discordant	Both APR elevated	P value
	n = 2,520	n = 1,058	n = 650
Age (years)	59.29 ± 13.22	62.21 ± 13.21	62.71 ± 13.34	<0.0001
Duration of RA (years)	11.01 ± 9.83	11.93 ± 10.68	10.91 ± 10.27	0.0406
One-year follow-up duration (days)	362.63 ± 30.51	363.33 ± 31.06	363.46 ± 32.03	0.7410
mHAQ	0.33 ± 0.40	0.45 ± 0.47	0.56 ± 0.54	<0.0001
CDAI	12.89 ± 10.15	15.18 ± 11.16	20.47 ± 14.68	<0.0001
Tender joints	3.73 ± 5.24	4.29 ± 5.40	6.30 ± 7.21	<0.0001*
Swollen joints	4.04 ± 5.13	4.80 ± 5.49	6.64 ± 6.42	<0.0001*
Patient global assessment	30.91 ± 23.82	36.35 ± 25.45	42.90 ± 27.56	<0.0001
MD global assessment	20.21 ± 16.61	24.67 ± 19.06	32.42 ± 22.50	<0.0001
Prednisone use	680 (26.98%)	341 (32.23%)	275 (42.31%)	<0.0001
Methotrexate use	1,668 (66.19%)	698 (65.97%)	417 (64.15%)	0.6166
Biologic use	1,263 (50.12%)	447 (42.25%)	224 (34.46%)	<0.0001

^*Log-linear model (Poisson) - χ² test. APR, acute phase reactant; RA, rheumatoid arthritis; mHAQ, modified Health Assessment Questionnaire; CDAI, Clinical Disease Activity Index.

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