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Table 4 Correlation of carotid and femoral artery intima-media thickness with traditional and nontraditional risk factors for atherosclerosis a

From: Atherosclerotic plaques occur in absence of intima-media thickening in both systemic sclerosis and systemic lupus erythematosus: a duplexsonography study of carotid and femoral arteries and follow-up for cardiovascular events

Variable SSc (n = 90) SLE (n = 100)
Mean CCA IMT Mean CFA IMT Mean CCA IMT Mean CFA IMT
Correlation P value Correlation P value Correlation P value Correlation P value
Age (years) r = 0.682 <0.001 r = 0.565 <0.001 r = 0.726 <0.001 r = 0.560 <0.001
Age at diagnosis (years) r = 0.652 <0.001 r = 0.586 <0.001 r = 0.670 <0.001 r = 0.437 <0.001
Disease duration (months) r = -0.030 0.782 r = -0.109 0.308 r = 0.094 0.357 r = 0.217 0.032
Male sex r φ = 0.261 0.013 r φ =0.341 0.001 r φ = 0.268 0.007 r φ = 0.208 0.039
Postmenopausal status r = 0.546 0.001 r = 0.375 0.001 r = 0.400 <0.001 r = 0.373 <0.001
Body mass index r = 0.128 0.241 r = 0.197 0.070 r = 0.258 0.012 r = 0.294 0.004
Systolic blood pressure (mmHg) r = 0.303 0.007 r = 0.332 0.003 r = 0.346 0.001 r = 0.171 0.124
Glomerular filtration rate r = -0.316 0.003 r = -0.489 <0.001 r = -0.296 0.003 r = -0.277 0.006
Nicotine pack-years r = 0.022 0.839 r = 0.320 0.002 r = 0.082 0.424 r = -0.058 0.570
Coronary heart disease r φ = 0.160 0.133 r φ = 0.379 <0.001 r φ = 0.265 0.008 r φ = 0.160 0.115
mRSS r = 0.225 0.036 r = -0.021 0.843 – – – –
SCL70 antibody r φ = -0.117 0.270 r φ = -0.209 0.048 – – – –
Centromere antibody r φ = 0.165 0.119 r φ = 0.255 0.015 – – – –
SLEDAI – – – – r = -0.166 0.115 r = -0.057 0.591
SLICC – – – – r = 0.208 0.049 r = 0.117 0.271
dsDNA antibody – – – – r φ = -0.188 0.063 r φ = -0.197 0.051
Nucleosomes antibody – – – – r φ = -0.231 0.021 r φ = -0.123 0.224
  1. CCA, common carotid artery; CFA, common femoral artery; dsDNA, double-stranded DNA; IMT, intima-media thickness; mRSS, modified Rodnan Skin Score; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics damage index; SSc, systemic sclerosis.
  2. aOnly variables suggested for multivariate linear regression analysis are reported; complete report available in Additional file 1.
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Arthritis Research & Therapy

ISSN: 1478-6362

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