General linear model adjusted for disease duration 11.34 years). (A) Estimated marginal means (EMM) of Health Assessment Questionnaire for patients within remission (REM), low disease activity (LDA), and moderate to high disease activity (MDA/HDA) of an RA patient with 11.34 years of disease duration. (B) EMM of Euro-QoL 5D of respective patients. (C) EMM of Short Form 6D; (D) EMM of Short Form 36 physical component score. Each model showed significant differences (P < 0.01) of respective outcomes within patients of different levels of disease activity determined by simplified disease activity index (SDAI).