Table 2 Summary of effects of platelet-rich plasma on mesenchymal stem cells from various tissue sources in vitro

Sheep BMSCs

Double-spun PRP activated by CaCl₂

Increased cell proliferation and Col II mRNA expression

[34]

Human BMSCs

50% platelet lysate after two cycles of freezing and thawing

Promoted proliferation and triggered chondrogenic differentiation

[55]

Human BMSCs

10% inactivated PRP (leukocyte concentration unreported)

Enhanced cell proliferation and Sox9, aggrecan and RUNX2 mRNA expression

[56]

Rabbit BMSCs, ADSCs

10% double-spun inactivated PRP

Increased cell proliferation and expression of Sox9, aggrecan, Col II and Col I mRNA and proteins

[21]

Mouse MDSCs

Double-spun PRP

Promoted cell proliferation, adhesion and migration of MDSCs, and increased number of cells producing Col II and cell apoptosis

[58]

Human subchondral progenitor cells

5% P-PRP after freezing and thawing

Increased cell migration and cartilaginous matrix formation, but did not affect osteogenic and adipogenic differentiation

[60]