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Table 4 Summary of animal studies of platelet-rich plasma for treatment of knee arthritis

From: Biology of platelet-rich plasma and its clinical application in cartilage repair

Model or disease

Intervention

Outcome

Reference

Traumatic OA model in rabbits induced by ACLT

Injections of PBS, PBS-microspheres, PRPr after thrombin and CaCl2 activation or PRPr-microspheres

OA occurred in 25% of the PBS group, 33% of the PBS-microsphere group, and 25% of the PRP group, but no joints in the PRP-microsphere group showed OA changes at 10 weeks

[65]

Non-traumatic OA model in rabbits induced by collagenase

P-PRP or saline intra-articular injection at 4 weeks after collagenase infiltration

Significantly lower macroscopic and microscopic scores in the PRP-treated group than in the saline-treated group at 8 weeks

[81]

BSA-induced rheumatoid arthritis model in pigs

Double-spun, inactivated PRP intra-articular injections or saline at 2 weeks and 4 weeks after BSA injection

PRP suppressed the decrease of proteoglycan and Col II content in cartilage and the increase of inflammatory cytokines in synovium and cartilage induced by BSA at 6 weeks

[82]

Primary OA or osteochondrosis in horses

Three P-PRP intra-articular injections at 2 week intervals

PRP diminished synovial effusion and lameness in the affected joints significantly during 1 year follow-up

[83]

  1. ACLT, anterior cruciate ligament transection; BSA, bovine serum albumin; Col, collagen; OA, osteoarthritis; PBS, phosphate buffered saline; P-PRP, pure platelet-rich plasma; PRP, platelet-rich plasma; PRPr, PRP releasate.