From: Biology of platelet-rich plasma and its clinical application in cartilage repair
Model or disease | Intervention | Outcome | Reference |
---|---|---|---|
Traumatic OA model in rabbits induced by ACLT | Injections of PBS, PBS-microspheres, PRPr after thrombin and CaCl2 activation or PRPr-microspheres | OA occurred in 25% of the PBS group, 33% of the PBS-microsphere group, and 25% of the PRP group, but no joints in the PRP-microsphere group showed OA changes at 10Â weeks | [65] |
Non-traumatic OA model in rabbits induced by collagenase | P-PRP or saline intra-articular injection at 4Â weeks after collagenase infiltration | Significantly lower macroscopic and microscopic scores in the PRP-treated group than in the saline-treated group at 8Â weeks | [81] |
BSA-induced rheumatoid arthritis model in pigs | Double-spun, inactivated PRP intra-articular injections or saline at 2Â weeks and 4Â weeks after BSA injection | PRP suppressed the decrease of proteoglycan and Col II content in cartilage and the increase of inflammatory cytokines in synovium and cartilage induced by BSA at 6Â weeks | [82] |
Primary OA or osteochondrosis in horses | Three P-PRP intra-articular injections at 2Â week intervals | PRP diminished synovial effusion and lameness in the affected joints significantly during 1Â year follow-up | [83] |