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Table 1 Competition by pegylated and control proteins for binding of anti-pegloticase Ab

From: Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout

Protein (200 μg/mL) Low positive control serum High positive control serum
Mean, A450nm Difference, % Mean, A450nm Difference, %
No protein 0.349   0.959  
Pegloticase 0.089 −74.5 0.254 −73.5
PEG-asparaginase 0.102 −70.8 0.326 −66.0
PEG-catalase 0.129 −63.0 0.289 −69.9
PEG-chymotrypsin 0.159 −54.4 0.491 −48.8
PEG-subtilisin 0.158 −54.7 0.423 −55.9
PEG-superoxide dismutase 0.244 −30.1 0.646 −32.6
Lysozyme/propylene oxide 0.324 −7.2 0.913 −4.8
  1. PEG, polyethylene glycol.