Table 1 Competition by pegylated and control proteins for binding of anti-pegloticase Ab
Protein (200 μg/mL) | Low positive control serum | High positive control serum | ||
|---|---|---|---|---|
Mean, A450nm | Difference, % | Mean, A450nm | Difference, % | |
No protein | 0.349 | 0.959 | ||
Pegloticase | 0.089 | −74.5 | 0.254 | −73.5 |
PEG-asparaginase | 0.102 | −70.8 | 0.326 | −66.0 |
PEG-catalase | 0.129 | −63.0 | 0.289 | −69.9 |
PEG-chymotrypsin | 0.159 | −54.4 | 0.491 | −48.8 |
PEG-subtilisin | 0.158 | −54.7 | 0.423 | −55.9 |
PEG-superoxide dismutase | 0.244 | −30.1 | 0.646 | −32.6 |
Lysozyme/propylene oxide | 0.324 | −7.2 | 0.913 | −4.8 |