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Table 4 Infusion reactions leading to withdrawal from study

From: Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

Patient ID (age) Number infusions Reactions Treatment/outcome
210 (50 y) 2 Nausea, dyspnea, hypoxemia, tachycardia, diaphoresis, hypotension, systemic rash IV fluids, O2, epinephrine, diphenhydramine; hospitalized overnight. All symptoms resolved.
213 (43 y) 3 Chills, nausea, chest tightness, systemic urticaria Infusion slowed, acetaminophen, diphenhydramine. All symptoms resolved.
219 (67 y) <1 Syncope Infusion stopped. All symptoms resolved.
237 (25 y) 3 Chest tightness, dyspnea, flushing, tachycardia Infusion stopped; diphenhydramine. All symptoms resolved.
241 (70 y) 2 Pruritus, chest tightness, hypotension, hypoxemia Infusion stopped; IV fluids, O2, diphenhydramine. All symptoms resolved.