TY - JOUR AU - Cheung, K. M. AU - Karppinen, J. AU - Chan, D. AU - Ho, D. W. AU - Song, Y. Q. AU - Sham, P. AU - Cheah, K. S. AU - Leong, J. C. AU - Luk, K. D. PY - 2009 DA - 2009// TI - Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals JO - Spine (Phila) VL - 34 UR - https://doi.org/10.1097/BRS.0b013e3181a01b3f DO - 10.1097/BRS.0b013e3181a01b3f ID - Cheung2009 ER - TY - JOUR AU - Roughley, P. J. PY - 2004 DA - 2004// TI - Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix JO - Spine (Phila) VL - 29 UR - https://doi.org/10.1097/01.brs.0000146101.53784.b1 DO - 10.1097/01.brs.0000146101.53784.b1 ID - Roughley2004 ER - TY - JOUR AU - Adams, M. A. AU - Roughley, P. J. PY - 2006 DA - 2006// TI - What is intervertebral disc degeneration, and what causes it? JO - Spine (Phila) VL - 31 UR - https://doi.org/10.1097/01.brs.0000231761.73859.2c DO - 10.1097/01.brs.0000231761.73859.2c ID - Adams2006 ER - TY - JOUR AU - Pittenger, M. F. AU - Mackay, A. M. AU - Beck, S. C. AU - Jaiswal, R. K. AU - Douglas, R. AU - Mosca, J. D. AU - Moorman, M. A. AU - Simonetti, D. W. AU - Craig, S. AU - Marshak, D. R. PY - 1999 DA - 1999// TI - Multilineage potential of adult human mesenchymal stem cells JO - Science VL - 284 UR - https://doi.org/10.1126/science.284.5411.143 DO - 10.1126/science.284.5411.143 ID - Pittenger1999 ER - TY - JOUR AU - Richardson, S. M. AU - Curran, J. M. AU - Chen, R. AU - Vaughan-Thomas, A. AU - Hunt, J. A. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2006 DA - 2006// TI - The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-L-lactic acid (PLLA) scaffolds JO - Biomaterials VL - 27 UR - https://doi.org/10.1016/j.biomaterials.2006.03.017 DO - 10.1016/j.biomaterials.2006.03.017 ID - Richardson2006 ER - TY - JOUR AU - Minogue, B. M. AU - Richardson, S. M. AU - Zeef, L. A. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2010 DA - 2010// TI - Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation JO - Arthritis Rheum VL - 62 UR - https://doi.org/10.1002/art.27710 DO - 10.1002/art.27710 ID - Minogue2010 ER - TY - JOUR AU - Sive, J. I. AU - Baird, P. AU - Jeziorsk, M. AU - Watkins, A. AU - Hoyland, J. A. AU - Freemont, A. J. PY - 2002 DA - 2002// TI - Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs JO - Mol Pathol VL - 55 UR - https://doi.org/10.1136/mp.55.2.91 DO - 10.1136/mp.55.2.91 ID - Sive2002 ER - TY - JOUR AU - Mwale, F. AU - Roughley, P. AU - Antoniou, J. PY - 2004 DA - 2004// TI - Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc JO - Eur Cell Mater VL - 8 ID - Mwale2004 ER - TY - JOUR AU - Minouge, B. M. AU - Richardson, S. M. AU - Zeef, L. A. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2010 DA - 2010// TI - Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes JO - Arthritis Res Ther VL - 12 UR - https://doi.org/10.1186/ar2929 DO - 10.1186/ar2929 ID - Minouge2010 ER - TY - JOUR AU - Bailey, A. J. PY - 2001 DA - 2001// TI - Molecular mechanisms of ageing in connective tissues JO - Mech Ageing Dev VL - 122 UR - https://doi.org/10.1016/S0047-6374(01)00225-1 DO - 10.1016/S0047-6374(01)00225-1 ID - Bailey2001 ER - TY - JOUR AU - Akhtar, R. AU - Sherratt, M. J. AU - Cruickshank, J. K. AU - Derby, B. PY - 2011 DA - 2011// TI - Characterizing the elastic properties of tissues JO - Mater Today (Kidlington) VL - 14 UR - https://doi.org/10.1016/S1369-7021(11)70059-1 DO - 10.1016/S1369-7021(11)70059-1 ID - Akhtar2011 ER - TY - JOUR AU - Sherratt, M. J. PY - 2009 DA - 2009// TI - Tissue elasticity and the ageing elastic fibre JO - Age (Dordr) VL - 31 UR - https://doi.org/10.1007/s11357-009-9103-6 DO - 10.1007/s11357-009-9103-6 ID - Sherratt2009 ER - TY - JOUR AU - Karsenty, G. AU - Wagner, E. F. PY - 2002 DA - 2002// TI - Reaching a genetic and molecular understanding of skeletal development JO - Dev Cell VL - 2 UR - https://doi.org/10.1016/S1534-5807(02)00157-0 DO - 10.1016/S1534-5807(02)00157-0 ID - Karsenty2002 ER - TY - JOUR AU - Settle, S. H. AU - Rountree, R. B. AU - Sinha, A. AU - Thacker, A. AU - Higgins, K. AU - Kingsley, D. M. PY - 2003 DA - 2003// TI - Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes JO - Dev Biol VL - 254 UR - https://doi.org/10.1016/S0012-1606(02)00022-2 DO - 10.1016/S0012-1606(02)00022-2 ID - Settle2003 ER - TY - JOUR AU - Asai-Coakwell, M. AU - French, C. R. AU - Ye, M. AU - Garcha, K. AU - Bigot, K. AU - Perera, A. G. AU - Staehling-Hampton, K. AU - Mema, S. C. AU - Chanda, B. AU - Mushegian, A. AU - Bamforth, S. AU - Doschak, M. R. AU - Li, G. AU - Dobbs, M. B. AU - Giampietro, P. F. AU - Brooks, B. P. AU - Vijayalakshmi, P. AU - Sauvé, Y. AU - Abitbol, M. AU - Sundaresan, P. AU - van Heyningen, V. AU - Pourquié, O. AU - Underhill, T. M. AU - Waskiewicz, A. J. AU - Lehmann, O. J. PY - 2009 DA - 2009// TI - Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes JO - Hum Mol Genet VL - 18 UR - https://doi.org/10.1093/hmg/ddp008 DO - 10.1093/hmg/ddp008 ID - Asai-Coakwell2009 ER - TY - JOUR AU - Le Maitre, C. L. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2009 DA - 2009// TI - Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells JO - Arthritis Res Ther VL - 11 UR - https://doi.org/10.1186/ar2808 DO - 10.1186/ar2808 ID - Le Maitre2009 ER - TY - JOUR AU - Gantenbein-Ritter, B. AU - Benneker, L. M. AU - Alini, M. AU - Grad, S. PY - 2011 DA - 2011// TI - Differential response of human bone marrow stromal cells to either TGF-β (1) or rhGDF-5 JO - Eur Spine J VL - 20 UR - https://doi.org/10.1007/s00586-010-1619-z DO - 10.1007/s00586-010-1619-z ID - Gantenbein-Ritter2011 ER - TY - JOUR AU - Stoyanov, J. V. AU - Gantenbein-Ritter, B. AU - Bertolo, A. AU - Aebli, N. AU - Baur, M. AU - Alini, M. AU - Grad, S. PY - 2011 DA - 2011// TI - Role of hypoxia and growth differentiation factor-5 on differentiation of human mesenchymal stem cells toward intervertebral nucleus pulposus like cells JO - Eur Cell Mater VL - 21 ID - Stoyanov2011 ER - TY - CHAP AU - Peroglio, M. AU - Eglin, D. AU - Benneker, L. M. AU - Alini, M. AU - Grad, S. PY - 2013 DA - 2013// TI - Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells BT - Spine J ID - Peroglio2013 ER - TY - JOUR AU - Feng, G. AU - Wan, Y. AU - Balian, G. AU - Laurencin, C. T. AU - Li, X. PY - 2008 DA - 2008// TI - Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells JO - Growth Factors VL - 26 UR - https://doi.org/10.1080/08977190802105917 DO - 10.1080/08977190802105917 ID - Feng2008 ER - TY - JOUR AU - Tassabehji, M. AU - Fang, Z. M. AU - Hilton, E. N. AU - McGaughran, J. AU - Zhao, Z. AU - de Bock, C. E. AU - Howard, E. AU - Malass, M. AU - Donnai, D. AU - Diwan, A. AU - Manson, F. D. AU - Murrell, D. AU - Clarke, R. A. PY - 2008 DA - 2008// TI - Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome JO - Hum Mutat VL - 29 UR - https://doi.org/10.1002/humu.20741 DO - 10.1002/humu.20741 ID - Tassabehji2008 ER - TY - JOUR AU - Wei, A. AU - Williams, L. A. AU - Bhargav, D. AU - Shen, B. AU - Kishen, T. AU - Duffy, N. AU - Diwan, A. D. PY - 2009 DA - 2009// TI - BMP13 prevents the effects of annular injury in an ovine model JO - Int J Biol Sci VL - 5 UR - https://doi.org/10.7150/ijbs.5.388 DO - 10.7150/ijbs.5.388 ID - Wei2009 ER - TY - JOUR AU - Zhao, X. AU - Akhtar, R. AU - Nijenhuis, N. AU - Wilkinson, S. J. AU - Murphy, L. AU - Ballestrem, C. AU - Sherratt, M. J. AU - Watson, R. E. AU - Derby, B. PY - 2012 DA - 2012// TI - Multi-layer phase analysis: quantifying the elastic properties of soft tissue and live cells with ultra-high-frequency scanning acoustic microscopy JO - IEEE Trans Ultrason Ferroelectr Freq Control VL - 59 UR - https://doi.org/10.1109/TUFFC.2012.2240 DO - 10.1109/TUFFC.2012.2240 ID - Zhao2012 ER - TY - JOUR AU - Graham, H. K. AU - Akhtar, R. AU - Kridiotis, C. AU - Derby, B. AU - Kundu, T. AU - Trafford, A. W. AU - Sherratt, M. J. PY - 2011 DA - 2011// TI - Localised micro-mechanical stiffening in the ageing aorta JO - Mech Ageing Dev VL - 132 UR - https://doi.org/10.1016/j.mad.2011.07.003 DO - 10.1016/j.mad.2011.07.003 ID - Graham2011 ER - TY - JOUR AU - Strassburg, S. AU - Richardson, S. M. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2010 DA - 2010// TI - Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype JO - Regen Med VL - 5 UR - https://doi.org/10.2217/rme.10.59 DO - 10.2217/rme.10.59 ID - Strassburg2010 ER - TY - JOUR AU - Purmessur, D. AU - Schek, R. M. AU - Abbott, R. D. AU - Ballif, B. A. AU - Godburn, K. E. AU - Iatridis, J. C. PY - 2011 DA - 2011// TI - Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells JO - Arthritis Res Ther VL - 13 UR - https://doi.org/10.1186/ar3344 DO - 10.1186/ar3344 ID - Purmessur2011 ER - TY - JOUR AU - Shen, B. AU - Bhargav, D. AU - Wei, A. AU - Williams, L. A. AU - Tao, H. AU - Ma, D. D. AU - Diwan, A. D. PY - 2009 DA - 2009// TI - BMP-13 emerges as a potential inhibitor of bone formation JO - Int J Biol Sci VL - 5 UR - https://doi.org/10.7150/ijbs.5.192 DO - 10.7150/ijbs.5.192 ID - Shen2009 ER - TY - JOUR AU - Livak, K. J. AU - Schmittgen, T. D. PY - 2001 DA - 2001// TI - Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method JO - Methods VL - 25 UR - https://doi.org/10.1006/meth.2001.1262 DO - 10.1006/meth.2001.1262 ID - Livak2001 ER - TY - JOUR AU - Farndale, R. W. AU - Buttle, D. J. AU - Barrett, A. J. PY - 1986 DA - 1986// TI - Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylene blue JO - Biochim Biophys Acta VL - 883 UR - https://doi.org/10.1016/0304-4165(86)90306-5 DO - 10.1016/0304-4165(86)90306-5 ID - Farndale1986 ER - TY - JOUR AU - Richardson, S. M. AU - Hughes, N. AU - Hunt, J. A. AU - Freemont, A. J. AU - Hoyland, J. A. PY - 2008 DA - 2008// TI - Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels JO - Biomaterials VL - 29 UR - https://doi.org/10.1016/j.biomaterials.2007.09.018 DO - 10.1016/j.biomaterials.2007.09.018 ID - Richardson2008 ER - TY - JOUR AU - Graham, H. K. AU - Trafford, A. W. PY - 2007 DA - 2007// TI - Spatial disruption and enhanced degradation of collagen with the transition from compensated ventricular hypertrophy to symptomatic congestive heart failure JO - Am J Physiol Heart Circ Physiol VL - 292 UR - https://doi.org/10.1152/ajpheart.00355.2006 DO - 10.1152/ajpheart.00355.2006 ID - Graham2007 ER - TY - JOUR AU - Li, Z. AU - Kupcsik, L. AU - Yao, S. J. AU - Alini, M. AU - Stoddart, M. J. PY - 2009 DA - 2009// TI - Chondrogenesis of human bone marrow mesenchymal stem cells in fibrin-polyurethane composites JO - Tissue Eng Part A VL - 15 UR - https://doi.org/10.1089/ten.tea.2008.0247 DO - 10.1089/ten.tea.2008.0247 ID - Li2009 ER - TY - JOUR AU - Clouet, J. AU - Grimandi, G. AU - Pot-Vaucel, M. AU - Masson, M. AU - Fellah, H. B. AU - Guigand, L. AU - Cherel, Y. AU - Bord, E. AU - Rannou, F. AU - Weiss, P. AU - Guicheux, J. AU - Vinatier, C. PY - 2009 DA - 2009// TI - Identification of phenotypic discriminating markers for intervertebral disc cells and articular chondrocytes JO - Rheumatology VL - 48 UR - https://doi.org/10.1093/rheumatology/kep262 DO - 10.1093/rheumatology/kep262 ID - Clouet2009 ER - TY - JOUR AU - Buckley, C. T. AU - Kelly, D. J. PY - 2012 DA - 2012// TI - Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs JO - J Mech Behav Biomed Mater VL - 11 UR - https://doi.org/10.1016/j.jmbbm.2011.09.004 DO - 10.1016/j.jmbbm.2011.09.004 ID - Buckley2012 ER - TY - JOUR AU - Turner, C. H. PY - 1999 DA - 1999// TI - The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques JO - J Biomech VL - 32 UR - https://doi.org/10.1016/S0021-9290(98)00177-8 DO - 10.1016/S0021-9290(98)00177-8 ID - Turner1999 ER - TY - JOUR AU - Hennig, T. AU - Lorenz, H. AU - Thiel, A. AU - Goetzke, K. AU - Dickhut, A. AU - Geiger, F. AU - Richter, W. PY - 2007 DA - 2007// TI - Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGF beta receptor and BMP profile and is overcome by BMP-6 JO - J Cell Physiol VL - 211 UR - https://doi.org/10.1002/jcp.20977 DO - 10.1002/jcp.20977 ID - Hennig2007 ER - TY - JOUR AU - Mazerbourg, S. AU - Sangkuhl, K. AU - Luo, C. W. AU - Sudo, S. AU - Klein, C. AU - Hsueh, A. J. PY - 2005 DA - 2005// TI - Identification of receptors and signalling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M504629200 DO - 10.1074/jbc.M504629200 ID - Mazerbourg2005 ER - TY - JOUR AU - Williams, L. A. AU - Bhargav, D. AU - Diwan, A. D. PY - 2008 DA - 2008// TI - Unveiling the bmp 13 enigma: redundant morphogen or crucial regulator? JO - Int J Biol Sci VL - 4 UR - https://doi.org/10.7150/ijbs.4.318 DO - 10.7150/ijbs.4.318 ID - Williams2008 ER - TY - JOUR AU - Clendenning, D. E. AU - Mortlock, D. P. PY - 2012 DA - 2012// TI - The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0036789 DO - 10.1371/journal.pone.0036789 ID - Clendenning2012 ER -