Locus | SNP | HR | 95% CI | P-value |
---|
GC
| rs2282679 | 2.52 | 1.05, 6.05 | 0.039 |
DHCR7/NADSYN1
| rs3829251 | 1.00 | 0.39, 2.56 | 1.00 |
rs12785878 | 0.71 | 0.22, 2.30 | 0.56 |
rs1790349 | 1.04 | 0.40, 2.65 | 0.94 |
CYP2R1
| rs10741657 | 1.31 | 0.58, 3.02 | 0.51 |
- All analyses were adjusted for independent non-genetic factors: Japanese version of the Health Assessment Questionnaire disability score, age, history of total knee replacement, and body mass index[16]. SNP, single nucleotide polymorphism; HR, hazard ratio; GC, group-specific component; DHCR7/NADSYN1, 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1; CYP2R1, cytochrome P450, family 2, subfamily R, polypeptide 1.