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Table 3 Hip fracture risk for rs2282679 (GC) and the other SNPs adjusted for independent non-genetic risk factors

From: A GC polymorphism associated with serum 25-hydroxyvitamin D level is a risk factor for hip fracture in Japanese patients with rheumatoid arthritis: 10-year follow-up of the Institute of Rheumatology, Rheumatoid Arthritis cohort study

Locus

SNP

HR

95% CI

P-value

GC

rs2282679

2.52

1.05, 6.05

0.039

DHCR7/NADSYN1

rs3829251

1.00

0.39, 2.56

1.00

rs12785878

0.71

0.22, 2.30

0.56

rs1790349

1.04

0.40, 2.65

0.94

CYP2R1

rs10741657

1.31

0.58, 3.02

0.51

  1. All analyses were adjusted for independent non-genetic factors: Japanese version of the Health Assessment Questionnaire disability score, age, history of total knee replacement, and body mass index[16]. SNP, single nucleotide polymorphism; HR, hazard ratio; GC, group-specific component; DHCR7/NADSYN1, 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1; CYP2R1, cytochrome P450, family 2, subfamily R, polypeptide 1.