Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study

Wang, Dandan; Li, Jing; Zhang, Yu; Zhang, Miaojia; Chen, Jinyun; Li, Xia; Hu, Xiang; Jiang, Shu; Shi, Songtao; Sun, Lingyun

doi:10.1186/ar4520

Table 3 Treatments used before and after umbilical cord mesenchymal stem cell transplantation in each patient ^a

From: Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study

Patient	Baseline	1 month	3 months	6 months	12 months
1	Pred 5 mg/d	Pred 5 mg/d,	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo,	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	LEF 20 mg/d	LEF 20 mg/d,	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
2	Pred 30 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d
2	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
3	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 15 mg/d	Pred 15 mg/d
	MMF 1.5 g/d	MMF 1.5 g/d	MMF 1.5 g/d	MMF 1.5 g/d	MMF 1.0 g/d
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
4	Pred 10 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 10 mg/d	LEF 10 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 200 mg/d
5	Pred 10 mg/d	Pred 10 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
6	Pred 20 mg/d	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	Triptolide 60 mg/d	Triptolide 60 mg/d
7	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo
	HCQ 300 mg/d	HCQ 300 mg/d	HCQ 300 mg/d	HCQ 300 mg/d	HCQ 300 mg/d
8	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 30 mg/d	Pred 10 mg/d
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 300 mg/d
9	Pred 40 mg/d	Pred 25 mg/d	Pred 15 mg/d	Pred 10 mg/d	/
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
10	Pred 10 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d
	LEF 20 mg/d	LEF 20 mg/d	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
11	Pred 20 mg/d	Pred 20 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.4 g/mo
	CYC 0.8 g/mo	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
12	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
12	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
13	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
14	Pred 15 mg/d	/	/	/	/
14	CYC 0.8 g/mo	/	/	/	/
15	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo,	CYC0.8 g/mo,	CYC 0.4 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 300 mg/d	HCQ 300 mg/d	HCQ 300 mg/d
16	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 20 mg/d
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
17	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/45 d	CYC 0.8 g/45d	CYC 0.4 g/mo
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
18	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
19	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 15 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo	CYC 0.8 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
20	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d	Pred 5 mg/d
	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d	MMF 0.5 g/d
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
21	Pred 7.5 mg/d	Pred 7.5 mg/d	Pred 5 mg/d	Pred 15 mg/d	Pred 15 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 200 mg/d
22	Pred 20 mg/d CYC 0.8 g/mo HCQ 400 mg/d	Pred 15 mg/d CYC 0.8 g/mo HCQ 400 mg/d	Pred 15 mg/d CYC 0.8 g/mo HCQ 400 mg/d	Pred 10 mg/d CYC 0.8 g/mo HCQ 400 mg/d	Pred 10 mg/d CYC 0.6 g/mo HCQ 400 mg/d
23	Pred 45 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 200 mg/d
24	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 5 mg/d	Pred 5 mg/d
24	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo
25	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d
	MMF 1.5 g/d	MMF 1.5 g/d	MMF 1.5 g/d	MMF 1.0 g/d	MMF 1.0 g/d
	LEF 10 mg/d	LEF 10 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d
26	Pred 20 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 20 mg/d
	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
27	Pred 50 mg/d	Pred 30 mg/d	Pred 15 mg/d	MP 80 mg/d	/
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/d × 3 d
	CsA 150 mg/d	CsA 150 mg/d	CsA 150 mg/d	γ-globulin 20 g × 3 d
28	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 5 mg/d	Pred 5 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
29	Pred 30 mg/d	Pred 25 mg/d	Pred 20 mg/d	Pred 10 mg/d	Pred 5 mg/d
	CYC 1.2 g/mo	CYC 1.2 g/mo	CYC 1.2 g/mo	CYC 1.2 g/mo	CYC 0.8 g/mo
	CYC 1.2 g/mo	CYC 1.2 g/mo	CYC 1.2 g/mo	Triptolide 60 mg/d	Triptolide 60 mg/d
30	Pred 25 mg/d	Pred 20 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC0.8 g/mo	CYC0.8 g/mo	CYC0.6 g/mo
	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 10 mg/d
31	Pred 30 mg/d	Pred 25 mg/d	Pred 25 mg/d	Pred 30 mg/d	Pred 15 mg/d
31	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d	MMF 1.0 g/d
32	Pred 25 mg/d	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d
	CYC 0.6 g/mo	CYC 0.6 g/mo	CYC 0.6 g/mo	CYC 0.6 g/mo	CYC 0.6 g/mo
	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 200 mg/d
33	Pred 25 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 35 mg/d	Pred 35 mg/d
34	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	LEF 20 mg/d	LEF 20 mg/d	LEF 10 mg/d	LEF 10 mg/d	LEF 10 mg/d
35	Pred 20 mg/d,	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
35	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo
36	Pred 25 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo	CYC 0.6 g/mo
	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 400 mg/d	HCQ 300 mg/d	HCQ 300 mg/d
37	Pred 20 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 15 mg/d	Pred 20 mg/d,
37	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d
38	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 7.5 mg/d	Pred 7.5 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.6 g/mo
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
39	Pred 20 mg/d	Pred 15 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d
	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo	CYC 0.8 g/mo
	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d	HCQ 200 mg/d
40	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 10 mg/d	Pred 5 mg/d
40	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d	LEF 20 mg/d

^aCsA Cyclosporine A; CYC, Cyclophosphamide; HCQ, Hydroxychloroquine; LEF, Leflunomide; MMF, Mycophenolate mofetil; MP, methylprednisone; MSCT, Mesenchymal stem cell transplantation; Pred, Prednisone; UC MSC, Umbilical cord–derived mesenchymal stem cells. Patients 1 to 26 were enrolled from the Department of Rheumatology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. Patients 27 to 32 were enrolled from the Department of Rheumatology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Patients 33 to 37 were enrolled from the Department of Rheumatology, Subei People’s Hospital of Jiangsu Province, Yangzhou, China. Patients 38 to 40 were enrolled from the Department of Rheumatology, Jiangsu Provincial People’s Hospital, Nanjing, China.

Back to article page

ISSN: 1478-6362

Contact us

General enquiries: journalsubmissions@springernature.com

Arthritis Research & Therapy

Contact us