Figure 3

Three-dimensional reconstruction images were created for use in qualitative analysis. Images were reconstructed using Mimics software (Materialise, Plymouth, MI, USA). (A) X-rays of control and surgically treated knees from wild-type (WT) and inactivated mitogen-inducible gene 6 (Mig-6^−/−) mice 2 and 4 weeks after surgery. Arrows point to subchondral bone erosion. (B) Three-dimensional reconstructed isosurfaces of knees from WT and Mig-6^−/−mice at 4 weeks after surgery. Arrows point to erosion and fragments in the subchondral bone. (C) Transverse view of three-dimensional reconstructed isosurfaces of trabecular bone from the distal femurs of WT and Mig-6^−/−knees 4 weeks after surgery. (D) Transverse view of three-dimensional reconstructed isosurfaces of trabecular bone from the proximal tibia of knees from WT and Mig-6^−/−knees 4 weeks after surgery.