Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury

Table 1 Tibia and femur trabecular bone micro-CT data ^a

Bone	WT		*Mig-6* ^−/−
Bone	Control	Surgery	Control	Surgery
Tibia
Trabecular BMD (g/ml)	0.579 ± 0.010	0.528 ± 0.006^b	0.524 ± 0.028^c	0.459 ± 0.009^b,d
Trabecular thickness (mm)	0.022 ± 0.000	0.022 ± 0.001	0.020 ± 0.001	0.021 ± 0.001^e,f
Number of trabeculae	5.918 ± 0.280	5.437 ± 0.405^b	4.395 ± 0.744	2.545 ± 0.187^g,h
Separation distance between trabeculae (mm)	0.138 ± 0.012	0.139 ± 0.004	0.242 ± 0.044	0.289 ± 0.063^e
BV/TV (%)	12.473 ± 0.483	13.042 ± 0.340	8.385 ± 1.780	10.670 ± 3.765
Femur
Trabecular BMD (g/ml)	0.590 ± 0.011	0.579 ± 0.015	0.551 ± 0.019	0.533 ± 0.022
Trabecular thickness (mm)	0.025 ± 0.001	0.023 ± 0.001	0.024 ± 0.002	0.031 ± 0.001^b,f
Number of trabeculae	6.214 ± 0.632	4.866 ± 0.419	3.716 ± 0.093ⁱ	4.573 ± 0.545
Separation distance between trabeculae (mm)	0.124 ± 0.009	0.158 ± 0.023	0.225 ± 0.040^c	0.190 ± 0.033
BV/TV (%)	16.502 ± 1.011	10.893 ± 1.069^b	11.747 ± 2.764	14.499 ± 2.678

^aBMD: Bone mineral density; BV/TV: Bone volume fraction (ratio of the segmented bone volume to the total volume of the region of interest); Mig-6^−/−: Inactivated mitogen-inducible gene 6; WT: Wild type. Animals that were X-rayed were also used for micro-CT analysis. Data are expressed as mean ± SE. ^bP < 0.05 between control and surgery. ^cP < 0.05 between genotypes for control knees. ^dP < 0.01 between genotypes for surgically treated knees. ^eP < 0.01 between control and surgery. ^fP < 0.001 between genotypes for surgically treated knees. ^gP < 0.001 between control and surgery. ^hP < 0.05 between genotypes for surgically treated knees. ⁱP < 0.01 between genotypes for control knees.

ISSN: 1478-6362