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Table 1 Tibia and femur trabecular bone micro-CT data a

From: Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury

Bone WT Mig-6 −/−
Control Surgery Control Surgery
Tibia     
Trabecular BMD (g/ml) 0.579 ± 0.010 0.528 ± 0.006b 0.524 ± 0.028c 0.459 ± 0.009b,d
Trabecular thickness (mm) 0.022 ± 0.000 0.022 ± 0.001 0.020 ± 0.001 0.021 ± 0.001e,f
Number of trabeculae 5.918 ± 0.280 5.437 ± 0.405b 4.395 ± 0.744 2.545 ± 0.187g,h
Separation distance between trabeculae (mm) 0.138 ± 0.012 0.139 ± 0.004 0.242 ± 0.044 0.289 ± 0.063e
BV/TV (%) 12.473 ± 0.483 13.042 ± 0.340 8.385 ± 1.780 10.670 ± 3.765
Femur     
Trabecular BMD (g/ml) 0.590 ± 0.011 0.579 ± 0.015 0.551 ± 0.019 0.533 ± 0.022
Trabecular thickness (mm) 0.025 ± 0.001 0.023 ± 0.001 0.024 ± 0.002 0.031 ± 0.001b,f
Number of trabeculae 6.214 ± 0.632 4.866 ± 0.419 3.716 ± 0.093i 4.573 ± 0.545
Separation distance between trabeculae (mm) 0.124 ± 0.009 0.158 ± 0.023 0.225 ± 0.040c 0.190 ± 0.033
BV/TV (%) 16.502 ± 1.011 10.893 ± 1.069b 11.747 ± 2.764 14.499 ± 2.678
  1. aBMD: Bone mineral density; BV/TV: Bone volume fraction (ratio of the segmented bone volume to the total volume of the region of interest); Mig-6−/−: Inactivated mitogen-inducible gene 6; WT: Wild type. Animals that were X-rayed were also used for micro-CT analysis. Data are expressed as mean ± SE. bP < 0.05 between control and surgery. cP < 0.05 between genotypes for control knees. dP < 0.01 between genotypes for surgically treated knees. eP < 0.01 between control and surgery. fP < 0.001 between genotypes for surgically treated knees. gP < 0.001 between control and surgery. hP < 0.05 between genotypes for surgically treated knees. iP < 0.01 between genotypes for control knees.