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Table 1 Data for the 141 JIA patients longitudinally evaluated in comparison to their respective control groups

From: Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone-mass determinants by using dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography

 

JIA group

Control group

 

Baseline

Second evaluation

Baseline

Second evaluation

Number of subjects

245

166

80

82

Female/male ratio

172:73

132:34

58:22

59:23

Age, years (range)

15.6 (9.6 - 28.3)

17.1 (11.0 - 28.9)

14.8 (8.9 - 26.7)

16.9 (10.9 - 28.4)

Height, z score

−0.6 ± 1.1

−0.5 ± 0.9

−0.1 ± 0.9

−0.1 ± 0.7

BMI, z score

−0.3 ± 0.8

−0.1 ± 0.6

0.1 ± 0.7

0.2 ± 0.5

Disease duration

5.6 ± 3.2 years

7.2 ± 4.3 years

-

-

C-HAQ DI

0.74 ± 0.63

0.59 ± 0.48

-

-

DXA examination

    

 BMC, g

45.17 ± 19.13a

49.04 ± 21.56°°°j

51.23 ± 17.90

56.98 ± 16.82h

 BMAD spine, g/cm2

−0.64 ± 0.80b

−0.49 ± 1.10°°°

0.24 ± 0.21

0.13 ± 0.32

HR-pQCT

    

 TrbBMD (mg/cm3)

179.5 ± 34.6c

181.9 ± 48.8f

217.7 ± 26.3

244.9 ± 28.5i

 CBA (mm2)

136.3 ± 122. c

149.0 ± 87.6f

209.2 ± 101.3

214.3 ± 74.3

 CrtBMD (mg/cm3)

1,050.2 ± 126.5

1,079.8 ± 82.1j

1,039.6 ± 79.3

1,078.3 ± 73.1g

 Muscle CSA (mm2)

2,112.7 ± 732.4b

2,083.7 ± 697.8f

2,398.5 ± 773.3

2,579.3 ± 794.5h

 Fat CSA (mm2)

1,143.1 ± 649.1c

1,110.1 ± 483.7e

918.3 ± 382.1

945.8 ± 394.2

 SSIp (mm3)

246.3 ± 140.2a

306.8 ± 250.7d,j

284.0 ± 127.9

276.7 ± 110.4

Ultrasonography

    

 -AD-SoS

1,994.5 ± 119.7b

2,003.0 ± 101.1e

2,122.3 ± 113.1

2,152.8 ± 118.9

 -QUS z score

−0.6 ± 1.8a

−0.5 ± 1.5e

0.1 ± 1.6

0.2 ± 1.8

  1. JIA versus controls (transversal study): aP < 0.05; bP < 0.005; cP < 0.0005; JIA versus. controls (longitudinal study): dP < 0.05; eP < 0.005; fP < 0.0005.
  2. Controls versus controls (longitudinal study): gP < 0.05; h^^ P < 0.005; iP < 0.0005; JIA versus JIA (longitudinal study): jP < 0.05; §j§P < 0.005; §§§ < 0.0005.
  3. AD-SoS, amplitude-dependent speed of sound; BMAD, bone mineral apparent density; BMC, bone mineral content; BMI, body mass index; CBA, cortical bone area; C-HAQ DI, Childhood Health Assessment Questionnaire Disability Index, range, 0–3 (0 = best, 3 = worst); CrtBMD, cortical bone-mineral density; DXA, dual-energy x-ray absorptiometry; FatCSA, fat cross-sectional area; HR-pQCT, high-resolution peripheral quantitative computed tomography; JIA, juvenile idiopathic arthritis; MuscleCSA, muscle cross-sectional area; SSIp, density-weighted polar section modulus; QUS, quantitative ultrasonography; TrbBMD, trabecular bone-mineral density.