Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone-mass determinants by using dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography

Stagi, Stefano; Cavalli, Loredana; Signorini, Carla; Bertini, Federico; Cerinic, Marco Matucci; Brandi, Maria Luisa; Falcini, Fernanda

doi:10.1186/ar4525

Table 3 Correlation coefficients (rho) between the bone traits and JIA characteristics in the JIA cohort and controls

From: Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone-mass determinants by using dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography

Bone traits	JIA phenotypes
	Type at onset	Age at onset	Disease duration	Disease activity	Flares	Chronologic age	MTX	Systemic corticosteroids	Intraarticular corticosteroids	Biological
TrbBMD	- 0.50**	−0.31**	-0.24**	−0.34**	−0.31**	0.05	0.28*	−0.56**	−0.48**	0.48**
	−0.39^^	−0.39^^	−0.43^^	−0.45^^	−0.29^	0.19	0.32^^	−0.61^^	−0.52^^	0.39^^
	-	-	-	-	-	0.74°°°	-	-	-	-
CrtBMD	0.08	0.32**	0.24*	−0.31**	−0.26*	0.64***	−0.28**	0.20	0.26*	0.36**
	0.16	0.37^^	0.28^	−0.28^^	−0.34^^	0.68^^^	−0.31^^	0.24^	0.24^	0.44^^
	-	-	-	-	-	0.89°°°	-	-	-	-
Tot density	−0.11	−0.14	- 0.40***	- 0.44***	- 0.38***	0.28*	−0.24*	−0.29*	−0.26*	0.32**
	−0.25^	−0.18	−0.38^^	−0.36^^	−0.42^^	0.36^^	−0.29^	−0.34^^	−0.28^	0.46^^
	-	-	-	-	-	0.62°°	-	-	-	-
CBA	0.08	−0.04	−0.18	−0.27*	−0.20*	0.46**	−0.22*	0.06	0.16	0.39**
	0.18	−0.16	−0.21^	−0.31^^	−0.24^	0.54^^	−0.31^^	0.14	0.14	0.28^
	-	-	-	-	-	0.79°°°	-	-	-	-
Bone area	−0.09	−0.12	−0.23*	−0.28*	−0.30*	0.09	−0.16	−0.16	−0.14	0.33**
	−0.12	−0.19	−0.27^	−0.21^	−0.34^^	0.10	−0.14	−0.28^	−0.34^^	0.49^^
	-	-	-	-	-	0.73°°°	-	-	-	-
MuscleCSA	−0.26**	−0.18	−0.16	−0.41**	−0.33**	0.35**	−0.17	−0.46**	−0.51***	0.26*
	−0.29^^	−0.24^	−0.25^	−0.46^^	−0.38^^	0.40^^	−0.08	−0.54^^^	−0.56^^^	0.38^^
	-	-	-	-	-	0.73°°°	-	-	-	-
FatCSA	31.9**	0.34**	0.18	0.35*	0.21*	0.04	0.26*	0.42**	0.26*	−0.19
	36.6^^	0.39^^	0.29^	0.28^	0.27^	0.13	0.39^^	0.39^^	0.84^^	−0.31^^
	-	-	-	-	-	0.23°	-	-	-	-
SSIp	0.03	0.09	0.56***	0.45**	0.38**	0.21*	0.36**	0.51***	0..46**	−0.29*
	0.17	0.19	0.48^^	0.49^^	0.32^^	0.23^	0.34^^	0.64^^^	0.39^^	−0.33^^
	-	-	-	-	-	−0.25°	-	-	-	-
BMAD	- 0.25*	0.48***	−0.34**	−0.46***	−0.38**	0.38**	- 0.39**	- 0.45**	- 0.40**	0.43**
	−0.23^	0.52^^^	−0.42^^	−0.51^^^	−0.34^^	0.47^^	−0,41^^	--0.49^^	−0.43^^	0.51^^^
	-	-	-	-	-	0.79°°°	-	-	-	-
BMD	0.16	0.34**	−0.27*	−0.36**	−0.27*	0.38**	−0.36**	−0.53***	−0.41**	0.29*
	0.19	0.36^^	−0.32^^	−0.39^^	−0.31^^	0.58^^	−0.44^^	−0.59^^^	−0.46^^	0.39^^
	-	-	-	-	-	0.88°°°	-	-	-	-
QUS z-score	- 0.25*	−0.27*	−0.35**	−0.41**	−0.22*	0.11	0.16	−0.38**	−0.36**	0.21*
	−0.21^	−0.33^^	−0.39^^	−0.33^^	−0.27^	−0.10	0.12	−0.46^^	−0.44^^	0.33^^
	-	-	-	-	-	0.17	-	-	-	-
AD-SoS	−0.18	−0.37**	−0.51***	−0.39**	−0.47**	0.69***	−0.24*	−0.59***	−0.57***	0.61***
	−0.23^	−0.42^^	−0.46^^	−0.31^^	−0.32^^	0.58^^^	−0.38^^	−0.65^^^	−0.51^^^	0.51^^^
	-	-	-	-	-	0.71°°°	-	-	-	-
BTT	−0.57***	−0.51***	−0.67***	−0.47**	−0.27*	0.43**	−0.36*	−0.61***	−0.65***	0.61***
	−0.62^^^	−0.64^^^	−0.52^^^	−0.43^^	−0.32^^	0.66^^	−0.48^^	−0.72^^^	−0.78^^^	0.67^^^
	-	-	-	-	-	0.84°°°°	-	-	-	-

The first line of each cell describes the correlation between bone parameters and JIA phenotypes during transversal study of JIA patients; the second line of each cell describes the correlation between bone parameters and JIA phenotypes during longitudinal study of JIA patients; the third line of each cell describes the correlation between bone parameters during transversal study of controls.
JIA transversal study: *P < 0.05; **P < 0.005; ***P < 0.0005; JIA longitudinal study: ^P < 0.05; ^^P < 0.005; ^^^P < 0.0005; Controls transversal study: °P < 0.05; °°P < 0.005; °°°P < 0.0005.
AD-SoS, amplitude-dependent speed of sound; BMAD, bone mineral apparent density; BMD, bone mineral density; BTT, bone transmission time; CBA, cortical bone area; CrtBMD, cortical bone mineral density; FatCSA, fat cross-sectional area; JIA, juvenile idiopathic arthritis; MTX, methotrexate; MuscleCSA, muscle cross-sectional area; QUS, quantitative ultrasonography; SSIp, density-weighted polar section modulus; TrbBMD, trabecular bone mineral density; Tot density, total density.

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