Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility

Table 5 Genetic analysis results

Polymorphism	Genotype	Group A (n = 20)	%	HWe P value	Group B (n = 21)	%	HWe P value	Group C (n = 21)	%	HWe P value
FRZB (rs288326; OS1A)
CC	WT	17	85	0.05	14	66.7	0.36	15	75	0.33
CT	H	2	10	0.05	7	33.3	0.36	4	20	0.33
TT	MUT	1	5		0	0		1	5
FRZB (rs7775; OS1B)
CC	WT	18	90	0.03	16	76.2	0.54	13	65	0.34
CG	H	2	10		5	23.8		7	35
GG	MUT	0	0		0	0		0	0
MATN3 (rs77245812; OS2)
CC	WT	19	95	0.91	20	95.2	0.91	18	90	0.81
CT	H	1	5		1	4.8		2	10
TT	MUT	0	0		0	0		0	0
ASPN (D14; OS3)
D13	WT	5	25	0.65	3	14.3	0.12	4	20	0.65
D13/D14	H	11	55		14	66.7		11	55
D14	MUT	4	20		4	19		5	25
PTH2R (rs144641723; OS4)
GG	WT	19	95	0.91	21	100	NA	20	100	NA
GT	H	1	5		0	0		0	0
TT	MUT	0	0		0	0		0	0
GDF5 (rs143383; OS5)
TT	WT	3	15	0.18	12	57.1	0.04	7	35	0.44
TC	H	13	65		5	23.8		11	55
CC	MUT	4	20		4	19		2	10
DVWA (rs11718863; OS6)
TT	WT	15	75	0.33	17	81	0.63	9	45	0.39
TA	H	4	20		4	19		10	50
AA	MUT	1	5		0	0		1	5

D, aspartic acid repeat; FRZB, frizzled-related protein; GDF5, growth and differentiation factor 5; H, heterozygote; HWe, Hardy–Weinberg equilibrium; MUT, homozygote; NA, not available; OS, osteoarthritis susceptibility; PTHR2, parathyroid hormone 2; WT, wild type.

ISSN: 1478-6362