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Table 6 Association between Kellgren and Lawrence osteoarthritis grading and genotype

From: Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility

Polymorphism KL group WT H + Mut P valuea
n % n %  
  A 17 85 3 15 0.39
FRZB-OS1A (rs288326) B 14 66.7 7 33.3
  C 15 75 5 25
  A 18 90 2 10 0.17
FRZB-OS1B (rs7775) B 16 76.2 5 23.8
  C 13 65 7 35
  A 19 95 1 5 0.75
MATN3-OS2 (rs77245812) B 20 95.2 1 4.8
  C 18 90 2 10
  A 5 25 15 75 0.69
ASPN-OS3 (D14) B 3 14.3 18 85.7
  C 4 20 16 80
  A 19 95 1 5 NA
PTH2R-OS4 (rs144641723) B 21 100 0 0
  C 20 100 0 0
  A 3 15 17 85 0.02
GDF5-OS5 (rs143383) B 12 57.1 9 42.9
  C 7 35 13 65
  A 15 75 5 25 0.03
DWVA-OS6 (rs11718863) B 17 81 4 19
  C 9 45 11 55
  1. D, aspartic acid repeat; FRZB, frizzled-related protein; GDF5, growth and differentiation factor 5; H, heterozygote; KL, Kellgren and Lawrence osteoarthritis grading scale; MUT, homozygote; n, number of patients; NA, not available; OS, osteoarthritis susceptibility; PTHR2, parathyroid hormone 2; WT, wild type. aChi-squared test.