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Table 6 Association between Kellgren and Lawrence osteoarthritis grading and genotype

From: Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility

Polymorphism

KL group

WT

H + Mut

P valuea

n

%

n

%

 
 

A

17

85

3

15

0.39

FRZB-OS1A (rs288326)

B

14

66.7

7

33.3

 

C

15

75

5

25

 

A

18

90

2

10

0.17

FRZB-OS1B (rs7775)

B

16

76.2

5

23.8

 

C

13

65

7

35

 

A

19

95

1

5

0.75

MATN3-OS2 (rs77245812)

B

20

95.2

1

4.8

 

C

18

90

2

10

 

A

5

25

15

75

0.69

ASPN-OS3 (D14)

B

3

14.3

18

85.7

 

C

4

20

16

80

 

A

19

95

1

5

NA

PTH2R-OS4 (rs144641723)

B

21

100

0

0

 

C

20

100

0

0

 

A

3

15

17

85

0.02

GDF5-OS5 (rs143383)

B

12

57.1

9

42.9

 

C

7

35

13

65

 

A

15

75

5

25

0.03

DWVA-OS6 (rs11718863)

B

17

81

4

19

 

C

9

45

11

55

  1. D, aspartic acid repeat; FRZB, frizzled-related protein; GDF5, growth and differentiation factor 5; H, heterozygote; KL, Kellgren and Lawrence osteoarthritis grading scale; MUT, homozygote; n, number of patients; NA, not available; OS, osteoarthritis susceptibility; PTHR2, parathyroid hormone 2; WT, wild type. aChi-squared test.