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Table 4 Age in relation to radiological progression a

From: Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study

Covariates OR 95% CI P-value
Age at disease onsetb 2.019 1.084 to 3.761 <0.05
Female sex 0.368 0.188 to 0.722 <0.01
ACPA-positive 2.179 1.117 to 4.251 <0.05
ESR (T0), mm/h 1.008 0.995 to 1.022 0.231
CVD-related comorbidityc 0.838 0.420 to 1.675 0.671
DMARD treatment within 3 month after T0, yes 1.400 0.594 to 3.298 0.442
  1. aACPA, Anticyclic citrullinated peptide/protein; CI: Confidence interval; CVD, Cardiovascular disease; DMARD, Disease-modifying antirheumatic drug; ESR, Erythrocyte sedimentation rate; OR: Odds ratio. bAge at disease onset stratified as young-onset rheumatoid arthritis <58 years old and late-onset rheumatoid arthritis ≥58 years old. cCVD-related comorbidity at time of inclusion (T0): CVD, hypertension or diabetes mellitus present before T0. Radiological progression is defined as the difference between Larsen score at 24 months and Larsen score at baseline (Δ Larsen score) ≥3. Data are derived from multiple logistic regression (n = 227).