Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study

Table 4 Age in relation to radiological progression ^a

Covariates	OR	95% CI	P-value
Age at disease onset^b	2.019	1.084 to 3.761	<0.05
Female sex	0.368	0.188 to 0.722	<0.01
ACPA-positive	2.179	1.117 to 4.251	<0.05
ESR (T0), mm/h	1.008	0.995 to 1.022	0.231
CVD-related comorbidity^c	0.838	0.420 to 1.675	0.671
DMARD treatment within 3 month after T0, yes	1.400	0.594 to 3.298	0.442

^aACPA, Anticyclic citrullinated peptide/protein; CI: Confidence interval; CVD, Cardiovascular disease; DMARD, Disease-modifying antirheumatic drug; ESR, Erythrocyte sedimentation rate; OR: Odds ratio. ^bAge at disease onset stratified as young-onset rheumatoid arthritis <58 years old and late-onset rheumatoid arthritis ≥58 years old. ^cCVD-related comorbidity at time of inclusion (T0): CVD, hypertension or diabetes mellitus present before T0. Radiological progression is defined as the difference between Larsen score at 24 months and Larsen score at baseline (Δ Larsen score) ≥3. Data are derived from multiple logistic regression (n = 227).

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