Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study

Table 5 Age in relation to radiological progression ^a

Covariates	OR	95% CI	P-value
Age at disease onset^b	1.842	1.014 to 3.348	<0.05
Female sex	0.361	0.189 to 0.692	<0.01
ACPA-positive	2.473	1.282 to 4.769	<0.01
ESR (T0), mm/h	1.010	0.997 to 1.024	0.136
CVD-related comorbidity^c	0.889	0.460 to 1.718	0.727
Corticosteroids (ever) ≤T5, yes	0.892	0.488 to 1.631	0.711

^aACPA, Anticyclic citrullinated peptide/protein; CI: Confidence interval; CVD, Cardiovascular disease; DMARD, Disease-modifying antirheumatic drug; ESR, Erythrocyte sedimentation rate; OR: Odds ratio. ^bAge at disease onset stratified as young-onset rheumatoid arthritis <58 years old and late-onset rheumatoid arthritis ≥58 years old. ^bCVD-related comorbidity at time of inclusion (T0): CVD, hypertension or diabetes mellitus present before T0. ^cRadiological progression is defined as the difference between Larsen score at 24 months and Larsen score at baseline (Δ Larsen score) ≥3. Data are derived from multiple logistic regression (n = 236).

ISSN: 1478-6362