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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques

Figure 1

Schematic overview of specific cells and molecules that can be targeted in the rheumatic joint. The rheumatoid synovium is characterized by the influx of inflammatory cells and release of cytokines. Surface molecules that are expressed on these cells can be used as markers to target and visualize the different cell types in the inflamed joint. DC-STAMP, dendritic cell-specific transmembrane protein; ICAM-1, intercellular adhesion molecule-1; IL, interleukin; MMP, matrix metalloproteinase; MMR, macrophage mannose receptor; OC-STAMP, osteoclast-stimulatory transmembrane protein; RA, rheumatoid arthritis; RANK, receptor activator of nuclear factor-kappa-B; RANKL, receptor activator of nuclear factor-kappa-B ligand; ST2, suppression of tumorigenicity 2; TNF-α, tumor necrosis factor-alpha; VCAM-1, vascular cell adhesion molecule-1.

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