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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques

Figure 4

In vivo imaging with macrophage mannose receptor (MMR)-specific nanobodies visualizes MMR expression in joints of mice with collagen-induced arthritis. Single-photon emission computed tomography and micro-computed tomography imaging was performed at 3 hours after injection of 99mtechnetium-labeled MMR-targeting nanobodies in mice without clinical symptoms of arthritis (A) (asymptomatic mice) or mice with arthritic joints (B) (symptomatic mice). Nanobodies against the β-lactamase BCII enzyme of Bacillus cereus (BCII10) were used as a non-targeting control. MMR staining is apparent in knees, ankles, and metatarsal joints of symptomatic mice (arrows) in addition to the signal in lymph nodes, liver, and spleen that is also detectable in asymptomatic mice. This image was originally published in the Journal of Nuclear Medicine[72]. © by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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