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Table 3 Distribution of B-cell subsets in patients and controls a

From: High levels of memory B cells are associated with response to a first tumor necrosis factor inhibitor in patients with rheumatoid arthritis in a longitudinal prospective study

B-cell subsets Controls All RA patients DMARD-naïve patients p1 p2 TNFi-naïve patients TNFi ongoing p3 Baseline TNFi introduction p4
Baseline 3 months
CD19+ 6.8 (2.5 to 8.7) 4.4 (3.3 to 6.1) 4.1 (3.1 to 9.6) NS NS 4.8 (3.6 to 7.4) 4.4 (3.1 to 6.3) NS 5.3 (3.9 to 6.3) 7.7 (6.7 to 10.6) **
(% lymphocytes)
CD27+ 22.0 (18.7 to 34.8) 25.4 (16.8 to 37.6) 34.4 (17.6 to 44.4) NS NS 25.2 (17.7 to 36.4) 30.0 (11.7 to 42.7) NS 28.3 (19.6 to 36.2) 28.4 (19.0 to 39.6) NS
(% CD19+)
CD27+IgD+ 10.4 (6.2 to 15.5) 8.0 (4.6 to 13.2) 8.0 (4.3 to 10.0) NS NS 8.0 (4.9 to 12.9) 10.5 (4.1 to 15.2) NS 9.3 (5.4 to 14.2) 7.5 (3.4 to 12.7) NS
(% CD19+)
CD27+IgD- 15.4 (10.2 to 21.7) 16.6 (11.0 to 25.3) 22.2 (13.8 to 39.1) NS NS 15.2 (10.7 to 24.4) 17.3 (9.2 to 28.6) NS 15.9 (12.7 to 24.5) 21.3 (13.2 to 24.8) NS
(% CD19+)
CD27-IgD+ 73.1 (58.2 to 77.1) 65.7 (54.2 to 77.1) 58.5 (45.4 to 74.8) NS NS 68.5 (56.8 to 77.0) 65.0 (50.9 to 82.1) NS 63.5 (54.4 to 76.7) 62.1 (49.6 to 73.7) NS
(% CD19+)
CD27-IgD- 2.8 (1.9 to 4.5) 4.7 (3.0 to 7.2) 5.8 (3.2 to 9.5) NS NS 4.7 (3.0 to 6.7) 3.8 (2.9 to 7.5) NS 4.7 (3.0 to 6.9) 6.8 (4.2 to 10.3) NS
(% CD19+)
  1. aDMARD, Disease-modifying antirheumatic drug; Ig, Immunoglobulin; NS, Not significant; p1, P-value comparing controls and all RA patients; p2, P-value comparing controls and DMARD-naïve patients; p3, P-value comparing TNFi-naïve and TNFi ongoing (currently taking TNFi agent); p4, P-value comparing baseline and 3-month data for patients with TNFi introduced at baseline; RA, Rheumatoid arthritis; TNFi, Tumor necrosis factor inhibitor. CD27+ memory B cells, CD27+IgD+ preswitch memory B cells, CD27+IgD- postswitch memory B cells, CD27-IgD+ naïve B cells, CD27-IgD- double-negative B cells, CD38high plasmablasts. All values are expressed in median (IQR). P-values were adjusted for age, sex and steroid dose.