Table 2 Frequency of CD4+ T cells and CD4 ⁺ CD25 ^+/high CD127 ^low/- regulatory T cells in the peripheral blood and synovial fluid and synovial membrane joint samples in rheumatoid arthritis and osteoarthritis patients ^a

PB

Sample size (n)

18

22

Sample volume (ml)

7 ± 0

7 ± 0

Concentration of CD4⁺ T cells (cells /μl)

730 ± 210

690 ± 90

0.424

<0.0001^b

<0.0001^b

<0.0001^b

<0.0001^b

(610 to 900)

(540 to770)

CD4⁺CD25^high (%total CD4⁺ T cells)

4.88 ± 2.04

4.4 ± 1.59

0.417

0.0072^b

0.0381^b

<0.0001^b

0.004^b

(2 to 9.4)

(1.9 to 8)

CD4⁺CD25^+/highCD127^low/- (% total CD4⁺ T cells)

6.7 ± 1.8

7.6 ± 1.8

0.135

0.0006^b

0.0128^b

0.0001^b

0.0091^b

(4 to 11)

(5 to 11)

CD4⁺CD25^+/highCD127^low/- (cells/μl)

48.9 ± 7.8

52.4 ± 4

0.099

<0.0001^b

0.0004^b

<0.0001^b

<0.0001^b

(30 to 99)

(29 to 85)

SF

Sample size (n)

17

22

Sample volume (ml)

15.41 ± 12.65

11.21 ± 6.81

(4.3 to 38)

(2.2 to 23.6)

Concentration of CD4⁺ T cells (cells/μl)

70 ± 170

40 ± 90

0.479

<0.0001^b

0.0001^b

<0.0001^b

<0.0001^b

(30 to 540)

(10 to 480)

CD4⁺CD25^high (% total CD4⁺ T cells)

9.97 ± 6.27

9.63 ± 4.12

0.7371

0.0072^b

0.2449

<0.0001^b

0.1086

(3.4 to 19)

(3.3 to 22.6)

CD4⁺CD25^+/highCD127^low/- (% total CD4⁺ T cells)

11.8 ± 5.5

12.4 ± 5

0.727

0.0006^b

0.1226

0.0001^b

0.4549

(5 to 22)

(4 to 26)

CD4⁺CD25^+/highCD127^low/- (cells/μl)

8.3 ± 9.4

5 ± 4.5

0.153

<0.0001^b

<0.0001^b

<0.0001^b

<0.0001^b

(8to90)

(4 to 100)

SM

Sample size (n)

18

22

Sample volume (mg)

3.45 ± 1.18

3.72 ± 1.3

(2.2 to 5.9)

(1.95 to 5.73)

Concentration of CD4⁺ T cells (cells/μg)

378 ± 250

240 ± 140

0.0336^b

<0.0001^b

0.0001^b

<0.0001^b

<0.0001^b

(10 to 610)

(10 to 340)

CD4⁺CD25^high (% total CD4⁺ T cells)

7.21 ± 3.9

7.5 ± 4.8

0.8354

0.0381^b

0.2449

0.004^b

0.1086

(2 to 18.4)

(2.5 to 26)

CD4⁺CD25^+/highCD127^low/- (% total CD4⁺ T cells)

9.4 ± 3.8

11.2 ± 5.9

0.266

0.0128^b

0.1226

0.0091^b

0.4549

(5 to 17)

(2.4 to 26)

CD4⁺CD25^+/highCD127^low/- (cells/μg)

35.5 ± 12

27 ± 11

0.025^b

0.0004^b

<0.0001^b

<0.0001^b

<0.0001^b

(24 to 89)

(14 to 73)