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Table 3 Phenotype characteristics of CD4 + CD25 +/high CD127 low/- T-cells from peripheral blood, synovial fluid and synovial membrane of rheumatoid arthritis and osteoarthritis patients a

From: CD4+CD25+/highCD127low/- regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood

  RA OA P-values
Surface marker PB SF SM PB SF SM RA OA PB SM
PB:SM PB:SM RA:OA RA:OA
CD45RA 22.9 ± 5 5 ± 3 2.8 ± 1 34.9 ± 13.6 6 ± 3 5.6 ± 2.5 0.0059b 0.0006c 0.0631 0.2377
21 (19.5 to 30.2) 4 (3 to 7) 2.8 (2 to 3.5) 30.8 (16.8 to 57.4) 7 (2 to 9) 6 (2.1 to 8.8)
CD45RO 83 ± 14.7 93 ± 7 94.7 ± 5.2 81.4 ± 8.5 92 ± 8 91.9 ± 7.2 0.4 0.0232b 0.9554 0.6488
81 (70 to 99) 92 (87 to 99) 94.9 (89.4 to 99) 82 (60 to 95) 91 (81 to 98) 94.3 (80.9 to 99.8)  
CD69 3.1 ± 1.9 88 ± 2 84.8 ± 0.2 1.9 ± 0.8 82.3 ± 5.3 81.2 ± 4.8 < 0.0001c 0.0029d 0.1623 0.4746
2.1 (1.9 to 5.2) 85 (80 to 92) 84.6 (78 to 89) 1.8 (0.9 to 3.7) 84 (77.3 to 88) 82.6 (74.6 to 84.9)
CD62L 94.6 ± 1.8 5 ± 2 2 ± 1 94.7 ± 4.4 3 ± 1 3.1 ± 0.5 < 0.0001c 0.0293b 0.8881 0.2480
94.5 (93.3 to 95.8) 3 (3 to 9) 2 (1.1 to 3.2) 95.3 (80.5 to 99.7) 3.5 (2 to 5) 3.1 (2.8 to 3.5)
CD152 12.6 ± 14 29.2 ± 12 36.2 ± 3.3 13 ± 6.5 31.5 ± 11 32.5 ± 8.2 0.0477b 0.0049d 0.7552 0.8530
5.7 (3.2 to 28.8) 33 (33 to 40) 36 (33 to 39) 16.3 (1 to 19) 30 (24 to 41) 32.5 (25 to 39.6)
CD154 13.5 ± 6.3 11 ± 5.7 15.1 ± 8.8 8.8 ± 5.4 12 ± 8 13.4 ± 8.2 0.5892 0.2863 0.2361 0.8486
13.4 (7 to 19.5) 13 (6 to 18) 15.1 (7 to 23) 8.5 (1.4 to 19) 11 (5 to 20) 10 (7.5 to 18)
CD274 23.5 ± 2.8 25 ± 7 27.6 ± 5.7 9.8 ± 10.4 25 ± 7 24.1 ± 7.9 0.3758 0.0313b 0.0329b 0.5541
23 (21 to 26) 32 (20 to 29) 31 (21 to 31) 6 (0.5 to 40) 26 (17 to 34) 24.1 (17 to 30.9)
CD279 3.3 ± 3.3 23.2 ± 12 22.6 ± 11 5.4 ± 6.5 9 ± 9 7.9 ± 10 0.0231b 0.6677 0.8127 0.0239b
3 (0.2 to 6.7) 24 (14 to 32) 22.6 (15 to 30.1) 2.2 (0 to 23.1) 8 (2 to 15) 8 (0.8 to 15)
GITR 30.3 ± 22.7 42.5 ± 7.3 45.5 ± 6.8 40.5 ± 12.8 49.2 ± 12 47.4 ± 11.9 0.329 0.173 0.636 0.8114
31.4 (7 to 52.4) 43 (39 to 51) 45.1 (38.9 to 52) 43.8 (18.4 to 59.1) 13.9 (33 to 59) 11.94 (30 to 58.7)
  1. aGITR, Glucocorticoid-induced tumour necrosis factor receptor–related protein; OA, Osteoarthritis; PB, Peripheral blood; RA, Rheumatoid arthritis; SF, Synovial fluid; SM, Synovial membrane. Significant differences: bP < 0.05; cP < 0.001; dP < 0.01. CD4+CD25+/highCD127low/- regulatory T cells from PB, SF and SM were stained for cell surface markers as indicated in the left column. The percentage of cells positive for each surface marker is presented as mean ± SD and median and range. Data are representative of three RA patients) and five OA patients. Statistical analysis is shown for PB and SM because SF values did not differ those for SM.