Skip to main content

Table 1 Summary of cytokine secretion by Mo and MoDC

From: Modulation of pro-inflammatory activation of monocytes and dendritic cells by aza-bis-phosphonate dendrimer as an experimental therapeutic agent

Cytokines (pg/ml) Control; median (IQR) LPS + IFN-γ; median (IQR) LPS + IFN-γ + ABP; median (IQR) P
Mo IL-12 0 (0; 0) 1 (0; 10) 0 (0; 0) 0.0159
Mo IL-10 0 (0; 5) 205 (110; 340) 328 (206; 369) ns
Mo TNFα 0 (0; 6) 617 (302; 912) 147 (82: 195) 0.0005
Mo IL-1β 0 (0; 4) 448 (232; 953) 261 (155; 688) 0.0186
Mo IL-6 175 (57; 403) 10,059 (5,074; 13,251) 11,682 (7,537; 17,425) ns
Mo IL-23 115 (99; 181) 277 (188; 521) 184 (137; 244) 0.036
MoDC IL-12 0 (0; 0) 45 (9; 166) 0 (0; 5) 0.0038
MoDC IL-10 0 (0; 0) 117 (53; 176) 228 (157; 260) 0.001
MoDC TNFα 0 (0; 5) 458 (374; 786) 241 (145, 481) 0.0033
MoDC IL-1β 0 (0; 0) 0 (0; 0) 0 (0, 8) ns
MoDC IL-6 13 (0; 29) 10,255 (7,262, 12,864) 8,131 (5,160; 11,310) ns
MoDC IL-23 130 (41; 152) 172 (104; 386) 134 (93; 249) ns
  1. Cytokines were measured in the supernatant of Mo and MoDC cultures. Concentrations were measured in the absence of stimulation (control) and after activation with LPS + IFN-γ with or without prior incubation with dendrimer ABP. Results are from 12 (Mo) and 11 (MoDC) blood donors, respectively. ABP, aza-bis-phosphonate; IFN-γ, interferon-gamma; IL, interleukin; IQR, interquartile range; LPS, lipopolysaccharide; Mo, monocytes; MoDC, monocyte derived dendritic cells.