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Table 1 Patient characteristics based on radiographic progression in two cohorts of rheumatoid arthritis patients a

From: 14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage

  Early RA (n = 33) Established RA (n = 40)
  No progression (SHS <1) Progression (SHS ≥1) P-value (U-test) No progression (SHS <1) Progression (SHS ≥1) P-value (U-test)
Patients, n 13 20 20 20
DAS28 ESR 5.0 (4.4 to 5.7) 6.1 (5.3 to 6.5) 0.04 1.9 (1.4 to 2.3) 1.9 (1.6 to 2.7) 0.56
Mean age (SD), yr 50.9 (5.2) 51.3 (5.0) 0.82 50.3 (10.6) 51.5 (13.9) 0.77
Sex, n (% female) 10 (77%) 13 (65%) 14 (70%) 16 (80%)
Baseline SHS 0 (0 to 0) 2.5 (1.0 to 6.8) 0.0002 1.0 (0 to 16) 38.7 (23.2 to 56.8) <0.0001
CRP, mg/L 12.0 (6.0 to 22.5) 12.5 (6.5 to 24.5) 0.82 3.0 (2.0 to 6.0) 8.0 (5.3 to 22.0) 0.001
RF, IU/ml 0 (0 to 160.0) 160.0 (40.0 to 320.0) 0.035 48.0 (2.0 to 68.0) 55.0 (19.5 to 223.8) 0.13
ACPA, U/ml 12 (6.5 to 96.0) 101.0 (14.3 to 194.3) 0.18 59.5 (20.3 to 365.9) 75.1 (20.3 to 440.3) 0.77
Mean 14-3-3η (SD), ng/ml 1.30 (3.51) 6.13 (8.33) 0.03 3.76 (6.92) 4.37 (8.02) 0.79
Median 14-3-3η (IQR), ng/ml 0.09 (0.06 to 12.59) 2.68 (0.12 to 15.94) 0.006 0.28 (0 to 4.54) 1.11 (0.10 to 2.89) 0.16
  1. aACPA, Anticitrullinated protein antibody; SHS, Sharp/van der Heijde score; CRP, C-reactive protein; DAS28 ESR, Disease Activity Score in 28 joints with erythrocyte sedimentation rate; RA, Rheumatoid arthritis; RF, Rheumatoid factor. P-values were calculated using the Mann–Whitney U test.