Table 1 Patient characteristics based on radiographic progression in two cohorts of rheumatoid arthritis patients a
Early RA (n = 33) | Established RA (n = 40) | |||||
|---|---|---|---|---|---|---|
No progression (SHS <1) | Progression (SHS ≥1) | P-value (U-test) | No progression (SHS <1) | Progression (SHS ≥1) | P-value (U-test) | |
Patients, n | 13 | 20 | – | 20 | 20 | – |
DAS28 ESR | 5.0 (4.4 to 5.7) | 6.1 (5.3 to 6.5) | 0.04 | 1.9 (1.4 to 2.3) | 1.9 (1.6 to 2.7) | 0.56 |
Mean age (SD), yr | 50.9 (5.2) | 51.3 (5.0) | 0.82 | 50.3 (10.6) | 51.5 (13.9) | 0.77 |
Sex, n (% female) | 10 (77%) | 13 (65%) | – | 14 (70%) | 16 (80%) | – |
Baseline SHS | 0 (0 to 0) | 2.5 (1.0 to 6.8) | 0.0002 | 1.0 (0 to 16) | 38.7 (23.2 to 56.8) | <0.0001 |
CRP, mg/L | 12.0 (6.0 to 22.5) | 12.5 (6.5 to 24.5) | 0.82 | 3.0 (2.0 to 6.0) | 8.0 (5.3 to 22.0) | 0.001 |
RF, IU/ml | 0 (0 to 160.0) | 160.0 (40.0 to 320.0) | 0.035 | 48.0 (2.0 to 68.0) | 55.0 (19.5 to 223.8) | 0.13 |
ACPA, U/ml | 12 (6.5 to 96.0) | 101.0 (14.3 to 194.3) | 0.18 | 59.5 (20.3 to 365.9) | 75.1 (20.3 to 440.3) | 0.77 |
Mean 14-3-3η (SD), ng/ml | 1.30 (3.51) | 6.13 (8.33) | 0.03 | 3.76 (6.92) | 4.37 (8.02) | 0.79 |
Median 14-3-3η (IQR), ng/ml | 0.09 (0.06 to 12.59) | 2.68 (0.12 to 15.94) | 0.006 | 0.28 (0 to 4.54) | 1.11 (0.10 to 2.89) | 0.16 |