Skip to main content

Table 3 Univariate association of clinical and laboratory variables with damage status and radiographic outcomes a

From: 14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage

Variable Early RA (n = 33) Established RA (n = 40)
Baseline damage status Progression Baseline damage status Progression
OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
DAS28 ESR 1.2 (0.7 to 2.3) 0.485 1.7 (0.9 to 3.6) 0.094 1.5 (0.5 to 4.9) 0.496 1.4 (0.6 to 3.5) 0.475
Age 1.0 (0.8 to 1.1) 0.505 1.0 (0.9 to 1.2) 0.815 1.1 (1.0 to 1.2) 0.112 1.0 (1.0 to 1.1) 0.763
Sex 2.8 (0.6 to 13.8) 0.192 1.8 (0.4 to 8.7) 0.462 1.0 (0.2 to 6.0) 0.660 1.7 (0.4 to 7.3) 0.358
CRP 1.0 (1.0 to 1.1) 0.084 1.0 (1.0 to 1.0) 0.906 1.6 (1.1 to 3.1) 0.004 1.1 (1.0 to 1.4) 0.003
ACPA + ve 1.1 (0.3 to 4.4) 0.580 2.2 (0.5 to 9.0) 0.239 7.7 (1.3 to 45.3) 0.022 2.2 (0.6 to 8.5) 0.214
RF + ve 2.5 (0.6 to 11.3) 0.195 9.1 (1.7 to 47.7) 0.008 10.3 (1.7 to 62.7) 0.010 1.2 (0.3 to 4.5) 0.500
14-3-3η         
 +ve ≥0.19 ng/ml 4.0 (0.9 to 17.2) 0.057 6.2 (1.3 to 30.2) 0.022 9.0 (1.5 to 53.9) 0.014 2.5 (0.6 to 9.4) 0.160
 +ve ≥0.40 ng/ml 5.5 (1.2 to 24.8) 0.025 10.2 (1.7 to 59.7) 0.006 4.4 (0.8 to 25.2) 0.089 4.3 (1.2 to 16.3) 0.028
 +ve ≥0.80 ng/ml 5.5 (1.2 to 24.8) 0.025 10.2 (1.7 to 59.7) 0.006 7.9 (0.8 to 25.2) 0.044 3.5 (0.9 to 13.0) 0.055
  1. aACPA, Anticitrullinated protein antibody; CI, Confidence interval; CRP, C-reactive protein; DAS28, Disease Activity Score in 28 joints; ESR, Erythrocyte sedimentation rate; OR, Odds ratio; RA, Rheumatoid arthritis; RF, Rheumatoid factor; +ve, Dependent variable increase for increase in independent variable. Variables with corresponding P-value ≤0.10 are presented in bold.