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Table 3 Univariate association of clinical and laboratory variables with damage status and radiographic outcomes a

From: 14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage

Variable

Early RA (n = 33)

Established RA (n = 40)

Baseline damage status

Progression

Baseline damage status

Progression

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

DAS28 ESR

1.2 (0.7 to 2.3)

0.485

1.7 (0.9 to 3.6)

0.094

1.5 (0.5 to 4.9)

0.496

1.4 (0.6 to 3.5)

0.475

Age

1.0 (0.8 to 1.1)

0.505

1.0 (0.9 to 1.2)

0.815

1.1 (1.0 to 1.2)

0.112

1.0 (1.0 to 1.1)

0.763

Sex

2.8 (0.6 to 13.8)

0.192

1.8 (0.4 to 8.7)

0.462

1.0 (0.2 to 6.0)

0.660

1.7 (0.4 to 7.3)

0.358

CRP

1.0 (1.0 to 1.1)

0.084

1.0 (1.0 to 1.0)

0.906

1.6 (1.1 to 3.1)

0.004

1.1 (1.0 to 1.4)

0.003

ACPA + ve

1.1 (0.3 to 4.4)

0.580

2.2 (0.5 to 9.0)

0.239

7.7 (1.3 to 45.3)

0.022

2.2 (0.6 to 8.5)

0.214

RF + ve

2.5 (0.6 to 11.3)

0.195

9.1 (1.7 to 47.7)

0.008

10.3 (1.7 to 62.7)

0.010

1.2 (0.3 to 4.5)

0.500

14-3-3η

        

 +ve ≥0.19 ng/ml

4.0 (0.9 to 17.2)

0.057

6.2 (1.3 to 30.2)

0.022

9.0 (1.5 to 53.9)

0.014

2.5 (0.6 to 9.4)

0.160

 +ve ≥0.40 ng/ml

5.5 (1.2 to 24.8)

0.025

10.2 (1.7 to 59.7)

0.006

4.4 (0.8 to 25.2)

0.089

4.3 (1.2 to 16.3)

0.028

 +ve ≥0.80 ng/ml

5.5 (1.2 to 24.8)

0.025

10.2 (1.7 to 59.7)

0.006

7.9 (0.8 to 25.2)

0.044

3.5 (0.9 to 13.0)

0.055

  1. aACPA, Anticitrullinated protein antibody; CI, Confidence interval; CRP, C-reactive protein; DAS28, Disease Activity Score in 28 joints; ESR, Erythrocyte sedimentation rate; OR, Odds ratio; RA, Rheumatoid arthritis; RF, Rheumatoid factor; +ve, Dependent variable increase for increase in independent variable. Variables with corresponding P-value ≤0.10 are presented in bold.
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Arthritis Research & Therapy

ISSN: 1478-6362

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