14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage

Table 4 Multivariate analyses indicating contribution of 14-3-3η to total variance in radiographic damage status and radiographic progression ^a

Cohort	Outcome		Without 14-3-3η	With 14-3-3η
Cohort	Outcome		Without 14-3-3η	≥0.2 ng/ml	≥0.4 ng/ml	≥0.8 ng/ml
Early RA	Joint damage status	Model LR	2.99	7.06	8.54	8.54
		p	0.084	0.029	0.014	0.014
		R ²	0.065	0.154	0.187	0.187
	Radiographic progression	Model LR	11.16	12.27	13.72	13.72
		P	0.004	0.007	0.003	0.003
		R ²	0.252	0.273	0.310	0.310
Established RA	Joint damage status	Model LR	12.35	13.94	12.36	12.76
		P	0.006	0.008	0.015	0.013
		R ²	0.376	0.425	0.377	0.389
	Radiographic progression	Model LR	8.78	9.71	13.78	13.13
		P	0.003	0.008	0.001	0.001
		R ²	0.167	0.185	0.262	0.250

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